Genomics of rapid adaptation in the lab and in the wild

项目摘要 适应是生物学中的基本概念。我的实验室旨在建立一个经验性和理论性丰富的理论 适应的问题。我们特别关注从基因组数据中推断适应和研究快速 实时进化。后者包括(I)在酵母中的实验进化(通过从头突变适应于 (Ii)果蝇在季节和生态时间尺度上的适应(从 (Iii)实验性肿瘤的发生、生长和进化。 小鼠肺癌模型(空间受限的工程化从头开始和自发改变 上下文)。这些项目利用了多样化的系统、高吞吐量和高功率的实验 模式，以及复杂多样的分析框架，但它们都侧重于总体需求 理解快速适应的动力。最终，我们的目标是构建一种进化适应理论。 这自然可以解释长期建立的进化模式，这是显而易见的 在基因组数据中，以及在短期实验中直接观察到的适应的短期动态 进化论的研究。

Project Summary Adaptation is the foundational concept in biology. My lab aims to build an empirically and theoretically rich theory of adaptation. We focus specifically on the inference of adaptation from genomic data and on the study of rapid evolution in real time. The latter include (i) experimental evolution in yeast (adaptation by de novo mutation in well-mixed clonal system), (ii) adaptation on seasonal and ecological time-scales in Drosophila (adaptation from standing variation in a obligately sexual organism), and (iii) tumor initiation, growth, and evolution in experimental mouse model of lung cancer (engineered de novo and spontaneous alterations in a spatially constrained context). These projects utilize a diversity of systems, high throughput and well-powered experimental modalities, and sophisticated and varied analytic frameworks, but they all focus on the overarching need to understand the dynamics of rapid adaptation. Ultimately, we aim to construct a theory of evolutionary adaptation that can naturally account for the patterns of evolution established over long periods of time, which are evident in genomic data, as well as the short-term dynamics of adaptation directly observable in short-term experimental studies of evolution.