Project 3: Systematic characterization of factors controlling breast cancer progression and resistance

项目3:控制乳腺癌进展和耐药因素的系统表征

基本信息

  • 批准号:
    10911510
  • 负责人:
  • 金额:
    $ 6.62万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-14 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

Summary of the Parent Grant Project 3: Systematic characterization of factors controlling breast cancer progression and resistance Two central challenges limit effectiveness of cancer therapies and enable metastasis: development of intrinsic resistance to targeted drugs, and development of resistance to recognition and destruction of cancer cells by the immune system. Traditional in vitro cancer models have been limited in scale and often lack key properties of the tumor microenvironment. We recently developed a scalable cancer spheroid system that enabled the first genome-wide CRISPR screens in 3D culture; phenotypes in this system much better reflect in vivo tumors (Han et al., 2020). In addition, we developed a magnetic separation strategy to rapidly identify regulators of phagocytosis by macrophages (Haney et al., 2018), and have successfully extended this strategy to study macrophage-tumor cell interactions. Here we propose to use these systems to identify regulators of resistance to targeted and endocrine therapies and macrophage killing in metastatic breast cancer. Aim 1: Identify critical drivers of growth and drug resistance in high relapse risk ER+ breast cancer cell lines and PDOs using CRISPRi/a screen Aim 2: Systematic identification and characterization of factors limiting macrophage phagocytosis of breast cancer cells
家长资助项目3的总结:控制乳房的因素的系统表征

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MICHAEL C BASSIK其他文献

MICHAEL C BASSIK的其他文献

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{{ truncateString('MICHAEL C BASSIK', 18)}}的其他基金

High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations
用于转录和染色质扰动的紧凑工具的高通量开发和表征
  • 批准号:
    10632140
  • 财政年份:
    2021
  • 资助金额:
    $ 6.62万
  • 项目类别:
Project 3: Systematic characterization of factors controlling breast cancer progression and resistance
项目3:控制乳腺癌进展和耐药因素的系统表征
  • 批准号:
    10704691
  • 财政年份:
    2021
  • 资助金额:
    $ 6.62万
  • 项目类别:
Project 3: Systematic characterization of factors controlling breast cancer progression and resistance
项目3:控制乳腺癌进展和耐药因素的系统表征
  • 批准号:
    10272391
  • 财政年份:
    2021
  • 资助金额:
    $ 6.62万
  • 项目类别:
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations
用于转录和染色质扰动的紧凑工具的高通量开发和表征
  • 批准号:
    10276866
  • 财政年份:
    2021
  • 资助金额:
    $ 6.62万
  • 项目类别:
High-throughput systematic characterization of regulatory element function
调控元件功能的高通量系统表征
  • 批准号:
    10238366
  • 财政年份:
    2020
  • 资助金额:
    $ 6.62万
  • 项目类别:
Development of novel protein-based therapeutics for lung cancer
开发基于蛋白质的新型肺癌疗法
  • 批准号:
    10373026
  • 财政年份:
    2018
  • 资助金额:
    $ 6.62万
  • 项目类别:
Development of novel protein-based therapeutics for lung cancer
开发基于蛋白质的新型肺癌疗法
  • 批准号:
    10133002
  • 财政年份:
    2018
  • 资助金额:
    $ 6.62万
  • 项目类别:
Development of novel protein-based therapeutics for lung cancer
开发基于蛋白质的新型肺癌疗法
  • 批准号:
    9894638
  • 财政年份:
    2018
  • 资助金额:
    $ 6.62万
  • 项目类别:
High-throughput systematic characterization of regulatory element function
调控元件功能的高通量系统表征
  • 批准号:
    9247643
  • 财政年份:
    2017
  • 资助金额:
    $ 6.62万
  • 项目类别:
Using Protein Interaction Networks and Combinatorial Screens to target KRAS driven cancer
使用蛋白质相互作用网络和组合筛选来靶向 KRAS 驱动的癌症
  • 批准号:
    9315124
  • 财政年份:
    2015
  • 资助金额:
    $ 6.62万
  • 项目类别:

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鉴定参与小鼠乳腺癌细胞系自发骨转移的新靶分子。
  • 批准号:
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CORE--BREAST CANCER CELL LINE RESOURCE
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    6663988
  • 财政年份:
    1999
  • 资助金额:
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  • 财政年份:
    1999
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    $ 6.62万
  • 项目类别:
CORE--BREAST CANCER CELL LINE RESOURCE
核心--乳腺癌细胞系资源
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    6102812
  • 财政年份:
    1998
  • 资助金额:
    $ 6.62万
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CORE--BREAST CANCER CELL LINE RESOURCE
核心--乳腺癌细胞系资源
  • 批准号:
    6269567
  • 财政年份:
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核心--乳腺癌细胞系资源
  • 批准号:
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乳腺癌及乳腺癌细胞系蛋白酶抑制剂的研究
  • 批准号:
    60480518
  • 财政年份:
    1985
  • 资助金额:
    $ 6.62万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
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