SOCIAL RELATIONS, AGING, AND CARDIOVASCULAR CHANGES

社会关系、衰老和心血管变化

• 批准号: 2327083
• 负责人: Bert N. Uchino
• 金额: $ 10万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-19 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2327083
• 关键词: age difference; aging; cardiovascular function; clinical research; disease /disorder proneness /risk; human subject; physiologic stressor; psychological stressor; social psychology; social support network

THIS IS A SHANNON AWARD PROVIDING PARTIAL SUPPORT FOR THE RESEARCH PROJECTS THAT FALL SHORT OF THE ASSIGNED INSTITUTE'S FUNDING RANGE BUT ARE IN THE MARGIN OF EXCELLENCE. THE SHANNON AWARD IS INTENDED TO PROVIDE SUPPORT TO TEST THE FEASIBILITY OF THE APPROACH; DEVELOP FURTHER TESTS AND REFINE RESEARCH TECHNIQUES; PERFORM SECONDARY ANALYSIS OR AVAILABLE DATA SETS; OR CONDUCT DISCRETE PROJECTS THAT CAN DEMONSTRATE THE PI'S RESEARCH CAPABILITIES OR LEND ADDITIONAL WEIGHT TO AN ALREADY MERITORIOUS APPLICATION. THE ABSTRACT BELOW IS TAKEN FROM THE ORIGINAL DOCUMENT SUBMITTED BY THE PRINCIPAL INVESTIGATOR. DESCRIPTION: Aging is typically associated with significant changes in cardiovascular function (e.g., increased blood pressure) that confer increased vulnerability to physical health problems. Research on chronological age and physiological function, however, suggests that physiological and chronological age are not isomorphic, and that social factors may play a role in the aging process. This application proposes to study the cardiovascular responses to laboratory stressors longitudinally for 144 men and women between the ages of 30 to 70. One aim of the proposal is to examine the influence of age on detailed invasive measures of resting cardiovascular function including systolic blood pressure, diastolic blood pressure, heart rate, systolic time intervals, cardiac output, and total peripheral resistance. Although age-related differences in standard resting measures of cardiovascular function (e.g., heart rate, blood pressure) are well-documented, much less is known about the influence of age on cardiovascular responses to psychological stressors. Therefore, a second aim of this research is to examine age-related differences and changes in cardiovascular reactivity during acute psychological stress. A third, and major aim of this research, is to examine a general conceptual model of the influence of positive and negative aspects of social relationships (e.g., social support, social conflict, social ambivalence) on such age-related differences and changes in resting cardiovascular activity and cardiovascular reactivity during acute psychological stress. Based on the proposed conceptual model, these investigators will also examine more specific psychological and behavioral factors that may be mediating these relationships.

这是一个香农奖提供部分支持的研究 项目不属于指定机构的资助范围，但 在优秀的边缘。香农奖旨在提供 支持测试方法的可行性;支持进一步测试 和完善研究技术;进行二次分析或提供 数据集;或进行离散项目，以证明PI 研究能力或为已经优秀的人提供额外的权重 应用程序.以下摘要摘自原始文件 由主要经销商提交。 描述：老化通常与以下方面的重大变化有关： 心血管功能（例如，血压升高）， 更容易受到身体健康问题的影响。 研究 然而，实际年龄和生理功能表明， 生理年龄和实足年龄不是同构的，社会年龄 因素可能在衰老过程中发挥作用。 本申请提出 研究实验室压力源对心血管的反应 年龄在30到70岁之间的144名男性和女性的纵向研究。 一 该提案的目的是研究年龄对详细的 静息心血管功能的侵入性测量，包括收缩压 血压、舒张压、心率、收缩时间 间期、心输出量和总外周阻力。 虽然 年龄相关的心血管标准静息测量差异 功能（例如，心率、血压）都有很好的记录， 关于年龄对心血管反应的影响， 心理压力源 因此，本研究的第二个目的是 研究年龄相关的心血管疾病的差异和变化， 急性心理应激时的反应。 第三个也是主要的目标是 本研究的目的，是探讨一个一般的概念模型的影响， 社会关系的积极和消极方面（例如，社会 支持，社会冲突，社会矛盾）对这种年龄相关的 静息心血管活动的差异和变化， 急性心理应激时的心血管反应。 基于 提出的概念模型，这些调查人员还将研究更多 特定的心理和行为因素可能是中介 这些关系。

项目成果

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients.

• DOI: 10.1186/s13024-017-0217-5
• 发表时间: 2017-10-24
• 期刊: Molecular neurodegeneration
• 影响因子: 15.1
• 作者: Konrad C;Kawamata H;Bredvik KG;Arreguin AJ;Cajamarca SA;Hupf JC;Ravits JM;Miller TM;Maragakis NJ;Hales CM;Glass JD;Gross S;Mitsumoto H;Manfredi G
• 通讯作者: Manfredi G

Age-related differences in cardiovascular reactivity during acute psychological stress in men and women.

男性和女性急性心理应激期间心血管反应性的年龄相关差异。

• DOI: 10.1093/geronb/54b.6.p339
• 发表时间: 1999
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Uchino,BN;Uno,D;Holt-Lunstad,J;Flinders,JB
• 通讯作者: Flinders,JB