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Novel role of innate immune DNA sensors in promoting gastric cancer

Novel role of innate immune DNA sensors in promoting gastric cancer
先天免疫DNA传感器在促进胃癌中的新作用
批准号:
nhmrc : 1139371
负责人:
Prof Brendan Jenkins
金额:
$52.33万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31

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中文摘要
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英文摘要
Stomach cancer is the third most lethal cancer worldwide, and is strongly associated with inflammation (gastritis) caused by Helicobacter pylori bacterial infection. However it remains unknown how Helicobacter triggers gastritis and stomach cancer in people. Using a mouse model for gastritis-associated stomach cancer, our aim is to demonstrate the role of immune system proteins in the stomach which detect bacterial and host DNA to drive chronic inflammatory responses that lead to stomach cancer.
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Targeting key regulators of innate immunity in inflammation-associated cancer
  • 批准号:
    nhmrc : GNT1154279
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.92万
  • 财政年份:
    2019
  • 负责人:
    Prof Brendan Jenkins
  • 依托单位:
Novel role of inflammasomes in the molecular pathogenesis of emphysema
  • 批准号:
    nhmrc : GNT1139373
  • 项目类别:
    Project Grants
  • 资助金额:
    $76.45万
  • 财政年份:
    2018
  • 负责人:
    Prof Brendan Jenkins
  • 依托单位:
Novel role of inflammasomes in the molecular pathogenesis of emphysema
  • 批准号:
    nhmrc : 1139373
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.69万
  • 财政年份:
    2018
  • 负责人:
    Prof Brendan Jenkins
  • 依托单位:
Novel role of innate immune DNA sensors in promoting gastric cancer
  • 批准号:
    nhmrc : GNT1139371
  • 项目类别:
    Project Grants
  • 资助金额:
    $77.4万
  • 财政年份:
    2018
  • 负责人:
    Prof Brendan Jenkins
  • 依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
  • 批准号:
    82371070
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    赵培泉
  • 依托单位: