IL-6 family cytokines and pathogen recognition receptors in inflammation-associated cancer

炎症相关癌症中的 IL-6 家族细胞因子和病原体识别受体

• 批准号: nhmrc : GNT1058261
• 负责人: Prof Brendan Jenkins
• 金额: $ 60.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/il-6-family-associated-cancer/1344636
• 关键词: IL; family; cytokines; pathogen; recognition

Lung and stomach cancer are the 2 most lethal cancers world-wide, and represent a growing number of cancers associated with chronic inflammation. However, the genes which trigger inflammation and then promote cancer in certain people remain largely unknown. Using mouse models for these inflammation-associated cancers, together with clinical specimens, our aim is to identify specific genes of the immune system which trigger chronic inflammatory responses that lead to cancer.

肺癌和胃癌是世界范围内两种最致命的癌症，并且代表了越来越多的与慢性炎症相关的癌症。然而，在某些人中引发炎症然后促进癌症的基因在很大程度上仍然未知。使用这些炎症相关癌症的小鼠模型，以及临床标本，我们的目标是确定免疫系统的特定基因，这些基因触发导致癌症的慢性炎症反应。