The molecular basis by which the interleukin-6 cytokine promotes emphysema

IL-6细胞因子促进肺气肿的分子基础

• 批准号: nhmrc : 1079475
• 负责人: Prof Brendan Jenkins
• 金额: $ 43.97万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-interleukin-promotes-emphysema/518667
• 关键词: molecular; basis; interleukin; cytokine; promotes

Interleukin 6 (IL-6) is a potent immuno-modulatory cytokine that is commonly elevated in emphysema, the 5th leading cause of death in Australia. To understand the role of IL-6 in emphysema, we aim to demonstrate here by using a unique mouse model for IL-6-driven emphysema and clinical biopsies from emphysema patients, that IL-6 uses an alternative signalling mechanism in emphysema termed trans-signalling. Therefore this project could provide novel therapeutic targets for emphysema.

白细胞介素6（IL-6）是一种有效的免疫调节细胞因子，通常在肺气肿中升高，肺气肿是澳大利亚第五大死亡原因。为了理解IL-6在肺气肿中的作用，我们的目的是通过使用IL-6驱动的肺气肿的独特小鼠模型和来自肺气肿患者的临床活检来证明IL-6在肺气肿中使用称为trans-signaling的替代信号传导机制。因此，本项目可能为肺气肿的治疗提供新的靶点。