The molecular basis by which IL-6 family cytokines and pathogen recognition receptors promote inflammation-associated stomach and lung cancer

IL-6家族细胞因子和病原体识别受体促进炎症相关胃癌和肺癌的分子基础

• 批准号: nhmrc : 1058261
• 负责人: Prof Brendan Jenkins
• 金额: $ 42.08万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-il-lung-cancer/454665
• 关键词: molecular; basis; IL; family; cytokines

Lung and stomach cancer are the 2 most lethal cancers world-wide, and represent a growing number of cancers associated with chronic inflammation. However, the genes which trigger inflammation and then promote cancer in certain people remain largely unknown. Using mouse models for these inflammation-associated cancers, together with clinical specimens, our aim is to identify specific genes of the immune system which trigger chronic inflammatory responses that lead to cancer.

肺癌和胃癌是世界上最致命的两种癌症，并且与慢性炎症相关的癌症越来越多。然而，在某些人群中引发炎症并进而引发癌症的基因在很大程度上仍然未知。使用这些炎症相关癌症的小鼠模型以及临床标本，我们的目标是识别触发导致癌症的慢性炎症反应的免疫系统的特定基因。