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Identification of interleukin-6 trans-signalling as a novel target for therapeutic approaches to lung cancer

Identification of interleukin-6 trans-signalling as a novel target for therapeutic approaches to lung cancer
鉴定白细胞介素 6 反式信号传导作为肺癌治疗方法的新靶点
批准号:
nhmrc : 1063998
负责人:
Prof Brendan Jenkins
金额:
$41.81万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31

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中文摘要
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英文摘要
Interleukin-6 (IL-6) has been implicated as a causative factor in lung cancer, the most lethal cancer worldwide, albeit by unknown mechanisms. Since IL-6 is also important for immune system homeostasis, the development of anti-IL-6 therapies requires an intimate knowledge of pathological versus physiological IL-6 signalling pathways. This project aims for the first time to define an alternative IL-6 signalling pathway, termed “trans signalling”, in the molecular pathogenesis of lung cancer.
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