Myeloid Cell Diversity: From Fundamental Biology to Disease States

摘要 要求为题为“骨髓细胞：机制、多样性和 活动由Andrés Hidalgo博士、Daniela Quail博士和Lai Guan Ng博士组织。会议将于 班夫，加拿大，2024年1月28日至31日。 骨髓细胞是先天免疫系统的主要组成部分，是炎症反应的第一反应者。 提示和关键从事持久的适应性免疫反应。了解基础生物学 在稳态和炎症环境中控制骨髓的发育和功能是必要的， 开发治疗方法以对抗癌症、心血管疾病、神经退化和其他疾病。与 随着单细胞技术的使用越来越多，骨髓多样性和异质性的巨大程度正在被 首次公布，创造了新的知识空白周围的骨髓功能状态的健康和 疾病本次Keystone研讨会将探讨变革性的研究概念，挑战 骨髓生物学的最新观点会议计划旨在利用尖端成像技术 技术来了解组织环境中的骨髓先天免疫功能。它还将促进 讨论将重新评估稳定状态下骨髓发育的基础生物学， 炎症，以及挑战目前的概念，我们如何定义骨髓细胞亚群与功能 states.该计划还将包括会议，将考虑训练的免疫力或生活方式的影响， 健康和疾病中的骨髓状态，并讨论了骨髓细胞代谢调节中的新概念， 疾病和衰老。与会者将了解可用于研究多样性的新工具和资源 在各种实验背景下的骨髓状态，并将面临挑战，重新思考现有的教条， 低估了骨髓细胞对健康和疾病的贡献。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Mechanisms, Diversity and Function, organized by Drs. Andrés Hidalgo, Daniela Quail and Lai Guan Ng. The conference will be held in Banff, Canada from January 28-31, 2024. Myeloid cells are major components of the innate immune system that are first responders to inflammatory cues and critical to engage long-lasting adaptive immune responses. Understanding the fundamental biology governing myeloid development and function in steady-state and inflammatory contexts is imperative to developing treatments to combat cancer, cardiovascular disease, neurodegeneration and other diseases. With the rising use of single cell technologies, the vast extent of myeloid diversity and heterogeneity is being unveiled for the first time, creating new knowledge gaps surrounding myeloid functional states in health and disease. This Keystone Symposia conference will explore transformative research concepts that challenge current views of myeloid biology. The conference program was designed to leverage cutting-edge imaging technologies to learn about myeloid innate immune functions across tissue environments. It will also promote discussions that will reevaluate the fundamental biology underlying myeloid development in steady-state and inflammation, as well as challenge current concepts of how we define myeloid cell subsets versus functional states. The program will also include sessions that will consider the impact of trained immunity or lifestyle on myeloid states in health and disease and discuss emerging concepts in metabolic regulation of myeloid cells in disease and aging. Attendees will learn about new tools and resources that are available to study the diversity of myeloid states in various experimental contexts and will be challenged to rethink existing dogma that underestimates the breadth of myeloid cell contributions to health and disease.