Myeloid Cell Diversity: From Fundamental Biology to Disease States

摘要 请求支持题为“骨髓细胞：机制、多样性和 功能，由博士组织。安德烈斯·伊达尔戈、丹妮拉·奎尔和吴赖冠。会议将于 2024 年 1 月 28 日至 31 日在加拿大班夫举行。 骨髓细胞是先天免疫系统的主要组成部分，是炎症的第一反应者 线索对于参与持久的适应性免疫反应至关重要。了解基础生物学 在稳态和炎症环境下控制骨髓的发育和功能对于 开发治疗癌症、心血管疾病、神经退行性疾病和其他疾病的疗法。与 随着单细胞技术的使用不断增加，骨髓的多样性和异质性正在被广泛研究。 首次揭晓，围绕健康和健康方面的骨髓功能状态创造了新的知识空白 疾病。本次 Keystone 研讨会将探讨挑战的变革性研究概念 骨髓生物学的当前观点。会议议程旨在利用尖端成像技术 技术来了解跨组织环境的骨髓先天免疫功能。也将促进 讨论将重新评估稳态和稳态下骨髓发育的基础生物学 炎症，并挑战当前我们如何定义骨髓细胞亚群与功能性细胞亚群的概念 州。该计划还将包括考虑经过训练的免疫力或生活方式对健康的影响的会议。 健康和疾病中的骨髓状态，并讨论骨髓细胞代谢调节的新概念 疾病和衰老。与会者将了解可用于研究多样性的新工具和资源 骨髓状态在各种实验环境中的变化，并将面临重新思考现有教条的挑战 低估了骨髓细胞对健康和疾病的贡献范围。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Mechanisms, Diversity and Function, organized by Drs. Andrés Hidalgo, Daniela Quail and Lai Guan Ng. The conference will be held in Banff, Canada from January 28-31, 2024. Myeloid cells are major components of the innate immune system that are first responders to inflammatory cues and critical to engage long-lasting adaptive immune responses. Understanding the fundamental biology governing myeloid development and function in steady-state and inflammatory contexts is imperative to developing treatments to combat cancer, cardiovascular disease, neurodegeneration and other diseases. With the rising use of single cell technologies, the vast extent of myeloid diversity and heterogeneity is being unveiled for the first time, creating new knowledge gaps surrounding myeloid functional states in health and disease. This Keystone Symposia conference will explore transformative research concepts that challenge current views of myeloid biology. The conference program was designed to leverage cutting-edge imaging technologies to learn about myeloid innate immune functions across tissue environments. It will also promote discussions that will reevaluate the fundamental biology underlying myeloid development in steady-state and inflammation, as well as challenge current concepts of how we define myeloid cell subsets versus functional states. The program will also include sessions that will consider the impact of trained immunity or lifestyle on myeloid states in health and disease and discuss emerging concepts in metabolic regulation of myeloid cells in disease and aging. Attendees will learn about new tools and resources that are available to study the diversity of myeloid states in various experimental contexts and will be challenged to rethink existing dogma that underestimates the breadth of myeloid cell contributions to health and disease.