Circulating Metabolic Intermediates as Fuels and Signals

作为燃料和信号的循环代谢中间体

• 批准号: 10753880
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.89万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753880
• 关键词: Address; Amino Acids; Benign; Biology; Cause of Death; Collaborations; Consensus; Data; Development; Diabetes Mellitus; Discipline; Disease; Educational workshop; Fatty acid glycerol esters; Future; Glucose; Goals; Health; Heart Diseases; Immune; Intervention; Knowledge; Learning; Malignant Neoplasms; Mentors; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Methodology; Muscle; Obesity; Outcome; Regulation; Research; Research Personnel; Role; Science; Scientist; Signal Transduction; Stroke; Succinates; Utah; Vision; clinical practice; design; disability; human disease; improved; microbiota; multidisciplinary; new technology; nonalcoholic steatohepatitis; novel therapeutic intervention; posters; prospective; symposium; synergism; translational potential; wasting

ABSTRACT Support is requested for a Keystone Symposia conference entitled Circulating Metabolic Intermediates as Fuels and Signals, organized by Drs. Sven Enerbäck, Joshua Rabinowitz and Sarah-Maria Fendt. The conference will be held in Snowbird, Utah from October 8-11, 2023. Metabolic diseases such as stroke, heart disease, diabetes, cancer, obesity, and NASH remain major causes of death and disability. One reason for this is due to the incomplete understanding of metabolism and its regulation. New data indicate that metabolites normally viewed as wastes or benign intermediates are actually very important fuels and signals. For example, lactate has emerged as an important energy substrate and succinate as a driver of muscle remodeling, reflecting the many underexplored roles of circulating metabolic intermediates. The importance of such intermediates, as opposed to classical “fuels” like glucose, amino acids and fat, opens a new perspective on how metabolism is controlled. Thus, this field is primed for further breakthroughs, both in understanding of new biology and in offering new targets for intervention. This Keystone Symposia conference will bring together the leading experts in the field to review the latest research and discuss challenges the field is facing. Finally, this conference is being held jointly with the Keystone Symposia conference on Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade. It is anticipated that this paring will lead to new scientific collaborations and the implementation of new technological approaches directed at understanding the underlying mechanisms of microbiota-immune and -metabolic interactions.

摘要 要求支持一个题为“循环代谢中间体作为燃料”的Keystone专题讨论会 由Sven Enerbäck、约书亚·拉比诺维茨和萨拉-玛丽亚·芬特博士组织。会议将 将于2023年10月8日至11日在犹他州雪鸟举行。 代谢性疾病如中风、心脏病、糖尿病、癌症、肥胖症和NASH仍然是导致肥胖的主要原因。 死亡和伤残。其中一个原因是由于对代谢及其调节的不完全理解。 新的数据表明，通常被视为废物或良性中间体的代谢物实际上非常 重要的燃料和信号。例如，乳酸盐已成为一种重要的能量底物， 作为肌肉重塑的驱动因素，反映了循环代谢中间体的许多未充分探索的作用。 与葡萄糖、氨基酸和脂肪等传统“燃料”相比， 一个关于新陈代谢是如何控制的新观点。因此，这一领域准备进一步突破，无论是在 了解新的生物学，并提供新的干预目标。Keystone Symposia会议 将汇集该领域的领先专家，审查最新的研究，并讨论该领域的挑战 面临着。最后，这次会议将与Keystone机制专题讨论会联合举行。 微生物群-免疫相互作用-走向下一个十年。预计这一削减将导致新的 科学合作和新技术方法的实施旨在了解 微生物群-免疫和-代谢相互作用的潜在机制。