STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL OF CELL PHONE RADIATION

该合同的目标是为国家毒理学计划(NTP)的危险评估活动提供支持，旨在预防癌症或其他可能因环境暴露于手机射频辐射(RFR)而产生的不良影响。研究所实验室的翻新工作已经完成，以满足NIEHS关于在实验动物身上进行手机射频辐射的毒性和致癌性研究的工作说明的要求。用于RFR曝光系统的自动浇水系统以及带有自动浇水系统歧管的原型笼架已经建造完成。搭建了一个原型混响室，并在该曝光系统中对射频场强度和均匀性进行了优化。位于伊利诺伊州芝加哥的IIT研究所实验室已经安装了用于评估手机射频辐射对大鼠和小鼠健康影响的曝光室以及暴露监测系统。这些系统的性能符合NIEHS对场强、场均匀度和射频信号特性的要求，已经由美国国家标准与技术研究院的工程师进行了独立测量。最近有证据表明，曝光室的环境条件(温度、相对湿度、空气流量)和场强得到了很好的保持，动物暴露预计将在09财年初开始。 手机；射频辐射；全球移动通信系统和码分多址信号；混响室；慢性毒性；致癌；血脑屏障渗漏；比吸收率；微核；DNA链断裂；大鼠；小鼠

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard assessment activities targeted toward the prevention of cancer or other adverse effects potentially caused by environmental exposure to cell phone radio frequency radiation (RFR). Renovation of the IIT Research Institute laboratories to meet the requirements of the NIEHS Statement of Work for the conduct of toxicity and carcinogenicity studies of cell phone RFR in laboratory animals has been completed. An automatic watering system for use in RFR exposure systems, as well as prototype cage racks with automatic watering system manifolds have been constructed. A prototype reverberation chamber was constructed and optimized for RF field strength and uniformity in this exposure system. Exposure chambers for evaluating health effects of cell phone RFR in rats and mice as well as exposure monitoring systems have been installed in the IIT Research Institute laboratories in Chicago, IL. The performance of these systems with respect to NIEHS requirements for field strength, field uniformity, and RF signal characteristics have been verified by independent measurements by engineers from the National Institute of Standards and Technology. With recent demonstration that environmental conditions (temperature, relative humidity, air flow) and field strengths in the exposure chambers are well maintained, animal exposures are expected to begin in early FY'09. Keywords cell phone; radio frequency radiation (RFR); GSM (Global System for Mobile Communications) and CDMA (Code Division for Multiple Access) signals; reverberation chambers; chronic toxicity; carcinogenicity; blood brain barrier leakage; specific absorption rate; micronuclei; DNA strand breaks; rats; mice