JHU Center for Neuroscience Research

描述（由申请人提供）：在这项支持神经科学研究的机构中心核心拨款中，我们建议建立三个核心设施。这些设施将提供必要的资源，并执行单个实验室无法单独提供的所需服务。它们由多光子成像/电生理核心、胚胎干细胞工程核心和单克隆抗体核心组成。这些核心提供的实验机会和技术服务是对约翰霍普金斯大学医学院（JHU SOM） nind资助的研究人员现有的核心设施的补充，而不是重复。这些核心设施的使用将极大地有利于构成本中心主要研究人员的十位nind资助的研究项目，它们也将是JHU SOM所有其他nind资助的研究人员的重要资源。该中心的10名主要研究人员中有9名是神经科学部门的成员，其余的研究人员是神经病学部门的成员。该中心主要研究人员的研究项目解决了神经发育、突触结构和功能调节、离子通道生理学和神经递质转运功能以及基因表达活性依赖性调节等领域尚未解决的问题。这些主要研究者的NINDS研究项目的具体目标是解决关键的临床问题，包括神经系统疾病的发育基础，损伤或变性后神经元再生的促进，以及神经退行性疾病（如阿尔茨海默氏痴呆症和ALS）的起源。该中心的主要研究人员定义了一个高度互动的群体，具有强大的无缝合作研究努力的历史。该中心的主要目标是为这些研究人员以及JHU SOM的所有其他nind资助的研究人员提供目前无法获得的核心设施，以增加他们现有的研究项目。

DESCRIPTION (provided by applicant): In this Institutional Center Core Grant to Support Neuroscience Research we propose to establish three Core facilities. These facilities will provide necessary resources and will perform required services that are impractical for individual laboratories to provide on their own. They consist of a Multiphoton Imaging/Electrophysiology Core, an Embryonic Stem Cell Engineering Core, and a Monoclonal Antibody Core. The experimental opportunities and technical services to be offered by these Cores complement and do not duplicate existing Core facilities available to NINDS-funded investigators at the Johns Hopkins University School of Medicine (JHU SOM). The use of these Core facilities will greatly benefit the NINDS funded research programs of the ten primary investigators who constitute the primary investigators of this Center, and they will also be an important resource for all other NINDS-funded investigators at JHU SOM. Nine of the Center's ten primary investigators are members of the Department of Neuroscience, and the remaining investigator is a member of the Department of Neurology. The research programs of the Center's primary investigators address unresolved issues in the areas of neural development, regulation of synaptic structure and function, ion channel physiology and neurotransmitter transporter function, and activity dependent regulation of gene expression. The Specific Aims of these primary investigator's NINDS research programs address critical clinical issues, including the developmental basis of neurological disorders, the promotion of neuronal regeneration folowing injury or degeneration, and the origin of neurodegenerative disorders such as Alzheimer's Dementia and ALS. The Center's Primary Investigators define a highly interactive group with a strong history of seamless collaborative research efforts. It is the primary goal of this Center to provide these investigators, and all other NINDS-funded investigators at JHU SOM with core facilities that are not currently available in order to augment their existing research programs.