JHU Center for Neuroscience Research

约翰霍普金斯大学神经科学研究中心

• 批准号: 7940708
• 负责人: ALEX L KOLODKIN
• 金额: $ 37.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7940708
• 关键词: Address; Alzheimer' s Disease; Area; Center Core Grants; Clinical; Complement; Core Facility; Dementia; Development; Electrophysiology (science); Funding; Gene Expression Regulation; Goals; Image; Individual; Injury; Ion Channel; Laboratories; Monoclonal Antibodies; National Institute of Neurological Disorders and Stroke; Natural regeneration; Neurodegenerative Disorders; Neurology; Neurons; Neurosciences; Neurosciences Research; Neurotransmitters; Physiology; Recording of previous events; Regulation; Research; Research Personnel; Resources; Services; Structure; Synapses; Universities; base; cellular engineering; embryonic stem cell; medical schools; member; nervous system disorder; neurodevelopment; programs

DESCRIPTION (provided by applicant): In this Institutional Center Core Grant to Support Neuroscience Research we propose to establish three Core facilities. These facilities will provide necessary resources and will perform required services that are impractical for individual laboratories to provide on their own. They consist of a Multiphoton Imaging/Electrophysiology Core, an Embryonic Stem Cell Engineering Core, and a Monoclonal Antibody Core. The experimental opportunities and technical services to be offered by these Cores complement and do not duplicate existing Core facilities available to NINDS-funded investigators at the Johns Hopkins University School of Medicine (JHU SOM). The use of these Core facilities will greatly benefit the NINDS funded research programs of the ten primary investigators who constitute the primary investigators of this Center, and they will also be an important resource for all other NINDS-funded investigators at JHU SOM. Nine of the Center's ten primary investigators are members of the Department of Neuroscience, and the remaining investigator is a member of the Department of Neurology. The research programs of the Center's primary investigators address unresolved issues in the areas of neural development, regulation of synaptic structure and function, ion channel physiology and neurotransmitter transporter function, and activity dependent regulation of gene expression. The Specific Aims of these primary investigator's NINDS research programs address critical clinical issues, including the developmental basis of neurological disorders, the promotion of neuronal regeneration folowing injury or degeneration, and the origin of neurodegenerative disorders such as Alzheimer's Dementia and ALS. The Center's Primary Investigators define a highly interactive group with a strong history of seamless collaborative research efforts. It is the primary goal of this Center to provide these investigators, and all other NINDS-funded investigators at JHU SOM with core facilities that are not currently available in order to augment their existing research programs.

描述（由申请人提供）：在这项机构中心核心赠款中，以支持我们建议建立三个核心设施的神经科学研究。这些设施将提供必要的资源，并将执行所需的服务，这些服务对于单个实验室而言是不切实际的。它们由多光子成像/电生理核心，胚胎干细胞工程核心和单克隆抗体核心组成。这些核心补充提供的实验机会和技术服务，并未复制约翰·霍普金斯大学医学院（JHU SOM）的Ninds资助的调查员可用的现有核心设施。这些核心设施的使用将极大地使Ninds资助的十个主要研究人员的研究计划构成该中心的主要研究人员，并且它们也将成为JHU SOM所有其他Ninds资助的研究人员的重要资源。该中心的十位主要研究人员中有9名是神经科学系的成员，其余的研究者是神经病学系的成员。该中心的主要研究人员的研究计划解决了神经发育领域的未解决问题，突触结构和功能的调节，离子通道生理学和神经递质转运蛋白转运蛋白的功能以及基因表达的活动依赖性调节。这些主要研究者的NINDS研究计划的具体目的解决了关键的临床问题，包括神经系统疾病的发育基础，促进神经元再生造成的损伤或退化，以及神经退行性疾病的起源，例如阿尔茨海默氏症的痴呆症和Als。该中心的主要研究人员定义了一个高度互动的团体，具有无缝的协作研究工作的悠久历史。该中心的主要目标是为这些调查员提供，以及JHU SOM的所有其他由NINDS资助的调查人员提供目前尚不可用的核心设施，以增强其现有的研究计划。