JHU Center for Neuroscience Research

描述(由申请人提供)：在这项支持神经科学研究的机构中心核心拨款中，我们建议建立三个核心设施。这些设施将提供必要的资源，并提供所需的服务，而这些服务是个别实验室单独提供的不切实际的。它们由多光子成像/电生理学核心、胚胎干细胞工程核心和单抗核心组成。这些核心将提供的实验机会和技术服务是对现有核心设施的补充，而不是与约翰霍普金斯大学医学院(JHU SOM)NINDS资助的研究人员现有的核心设施重复。这些核心设施的使用将极大地有利于NINDS资助的研究项目，他们是该中心的主要调查人员，他们也将是JHU SOM所有其他NINDS资助的调查人员的重要资源。该中心的十名主要研究人员中有九名是神经科学系的成员，剩下的一名研究人员是神经科学系的成员。该中心主要研究人员的研究计划解决了神经发育、突触结构和功能的调节、离子通道生理学和神经递质转运体功能以及依赖活动的基因表达调节等领域的悬而未决的问题。这些主要研究人员的NINDS研究项目的具体目标是解决关键的临床问题，包括神经疾病的发育基础，促进损伤或变性后的神经元再生，以及阿尔茨海默氏症和ALS等神经退行性疾病的起源。该中心的主要研究人员定义了一个高度互动的小组，具有强大的无缝协作研究努力的历史。该中心的主要目标是为这些研究人员以及JHU SOM的所有其他由NINDS资助的研究人员提供目前尚不具备的核心设施，以增强他们现有的研究计划。

DESCRIPTION (provided by applicant): In this Institutional Center Core Grant to Support Neuroscience Research we propose to establish three Core facilities. These facilities will provide necessary resources and will perform required services that are impractical for individual laboratories to provide on their own. They consist of a Multiphoton Imaging/Electrophysiology Core, an Embryonic Stem Cell Engineering Core, and a Monoclonal Antibody Core. The experimental opportunities and technical services to be offered by these Cores complement and do not duplicate existing Core facilities available to NINDS-funded investigators at the Johns Hopkins University School of Medicine (JHU SOM). The use of these Core facilities will greatly benefit the NINDS funded research programs of the ten primary investigators who constitute the primary investigators of this Center, and they will also be an important resource for all other NINDS-funded investigators at JHU SOM. Nine of the Center's ten primary investigators are members of the Department of Neuroscience, and the remaining investigator is a member of the Department of Neurology. The research programs of the Center's primary investigators address unresolved issues in the areas of neural development, regulation of synaptic structure and function, ion channel physiology and neurotransmitter transporter function, and activity dependent regulation of gene expression. The Specific Aims of these primary investigator's NINDS research programs address critical clinical issues, including the developmental basis of neurological disorders, the promotion of neuronal regeneration folowing injury or degeneration, and the origin of neurodegenerative disorders such as Alzheimer's Dementia and ALS. The Center's Primary Investigators define a highly interactive group with a strong history of seamless collaborative research efforts. It is the primary goal of this Center to provide these investigators, and all other NINDS-funded investigators at JHU SOM with core facilities that are not currently available in order to augment their existing research programs.