JHU Center for Neuroscience Research

描述（由申请人提供）：在我们的机构中心核心拨款的竞争性更新中，我们建议维持和扩大约翰霍普金斯大学医学院（JHU SOM）现有的三个核心设施的运作，这些设施是在本中心拨款的上一个资助期内建立的：多光子成像核心，单克隆抗体核心和胚胎干细胞工程核心。这些设施目前提供了必要的资源，并提供了单个实验室无法单独提供的所需服务。通过提供独特的设备、新方法的培训和新试剂的开发，这些核心设施的使用将继续极大地受益于ninds资助的11位主要中心调查员和JHU SOM的其他ninds资助的研究人员的研究项目。这三个核心提供的实验机会和技术服务是对JHU SOM国家科学研究院资助的研究人员可用的其他核心设施的补充，但不是重复。11位初级中心调查员中有7位是神经科学部门的成员，4位是神经病学部门的成员，1位是病理学部门的成员。初级中心研究人员的研究项目解决了神经和胶质发育、突触结构和功能、感觉转导以及基因表达的活动依赖性调节等领域尚未解决的问题。ninds资助的研究项目的主要目的是解决关键的临床问题，包括神经系统疾病的发育起源，损伤或退化后神经元再生的促进，神经性疼痛的潜在基础，以及神经退行性疾病（阿尔茨海默氏痴呆症和肌萎缩侧索硬化症）的起源。初级研究中心的研究人员组成了一个高度互动的小组，有着无缝合作研究的历史。该中心的目标是通过为JHU SOM的这些研究人员和其他nind资助的研究人员提供本机构其他地方无法获得的核心设施，从而扩大现有的研究项目。

DESCRIPTION (provided by applicant): In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that are impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDS-funded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology, and one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression. The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.