PERTURBATION MONTE CARLO TECHNIQUES FOR DIFFUSE PHOTON MIGRATION

漫射光子迁移的扰动蒙特卡洛技术

• 批准号: 8169428
• 负责人: VASAN VENUGOPALAN
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169428
• 关键词: Algorithms; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Diffuse; Funding; Grant; Heterogeneity; Institution; Methods; Optics; Photons; Property; Research; Research Personnel; Resources; Signal Transduction; Solutions; Source; Techniques; Tissues; United States National Institutes of Health; migration; novel; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Development has continued of a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then supply the derivative information to a nonlinear optimization algorithm to determine the optical properties of the tissue heterogeneity under consideration. We have demonstrated this approach in two layered media as well as more complex tissue geometries descriptive of particular applications.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 开发继续采用了一种新颖而有效的方法，可以为异构浊度培养基中的逆光子迁移问题提供解决方案。该方法从单个蒙特卡洛模拟中提取衍生信息，以允许在背景组织光学特性中快速确定检测到的光子信号的变化速率。然后，我们将衍生信息提供给非线性优化算法，以确定所考虑的组织异质性的光学特性。我们已经在两种分层介质以及更复杂的组织几何形状描述了特定应用中证明了这种方法。