ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS ANIMAL MODEL

无特定病原体恒河猴和猪艾滋病动物模型的建立

• 批准号: 8359542
• 负责人: Michael K Axthelm
• 金额: $ 12.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359542
• 关键词: AIDS Vaccines; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Animal Model; Animals; Bioterrorism; Breeding; Country; Disease; Ensure; Female; Future; Genetic; Investments; Macaca mulatta; Microbial Genetics; Modeling; Pathogenesis; Production; Research; Research Infrastructure; Resources; Solutions; Source; Specific Pathogen Frees; Target Populations; Vaccine Research; enzootic; germ free condition; improved; nonhuman primate; offspring; programs

DESCRIPTION (provided by applicant): The projected need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Given the increase in nonhuman primate use for AIDS-related opportunistic infection research, and their projected use for research focused on emerging disease and agents exploitable for bioterrorism, this shortage will likely continue for years to come. While source countries are a potentially important reserve of untapped production, the increasing difficulty of transporting nonhuman primates both internationally and domestically suggests relying on imports may provide only short term relief. Further, nonhuman primates with the level of genetic and microbial characterization prerequisite for many research models are currently not available from source country production resources. Domestic breeding programs managed to produce the well characterized animals necessary for cutting-edge research offer the best long-term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies. Investment in domestic breeding programs will also insure future availability. The comprehensive objective of this application is to increase the capacity of the ONPRC AIDS Research Expanded SPF Breeding Colony to provide genetically characterized Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance the usefulness of the resource for cutting edge opportunistic agent and vaccine research. The specific aims for accomplishing this objective are to a) maintain and continue to expand the ONPRC AIDS Research Expanded SPF Rhesus Macaque Breeding Colony to a target population of 100adult breeder females capable of producing 35 surplus animals annually for research use, b) optimize the potential usefulness of rhesus macaques produced in the ONPRC AIDS Research Expanded SPF Breeding Colony for vaccine research by ensuring SPF status and managing the colony for the production of offspring of known parentage and genetic background that are MHC-defined, and c) improve infrastructure necessary to maintain the ONPRC AIDS Research Expanded SPF Rhesus Macaque Breeding Colony as a closed and protected resource.

描述（由申请人提供）：预计对印度恒河猴进行艾滋病相关研究的需求将继续超过可用性。鉴于非人灵长类动物用于艾滋病相关机会性感染研究的增加，以及它们预计用于研究新兴疾病和可用于生物恐怖主义的制剂，这种短缺可能会持续多年。虽然来源国是潜在的未开发生产的重要储备，但国际和国内运输非人灵长类动物的难度越来越大，这表明依赖进口可能只能提供短期缓解。此外，具有许多研究模型所需的遗传和微生物特征的非人灵长类动物目前无法从来源国生产资源中获得。国内育种计划设法生产尖端研究所需的良好特征的动物，为目前缺乏印度恒河猴用于艾滋病疫苗和发病机制研究提供了最佳的长期解决方案。对国内育种计划的投资也将确保未来的可用性。本申请的综合目标是提高ONPRC艾滋病研究扩大SPF繁殖群的能力，以提供具有遗传特征的印度原产恒河猴，不含大量的地方病和人畜共患病病原体，从而提高该资源在尖端机会病原体和疫苗研究中的有用性。实现这一目标的具体目标是：a）维持并继续扩大ONPRC AIDS研究扩大SPF恒河猴繁殖群，目标种群为100只成年雌性繁殖猴，每年能够生产35只多余动物用于研究，B）通过确保SPF状态，优化ONPRC艾滋病研究扩大SPF繁殖群中生产的恒河猴在疫苗研究中的潜在用途，管理殖民地，以生产具有已知亲本和MHC定义的遗传背景的后代，和c）改善维持ONPRC AIDS研究扩展SPF猕猴繁殖群作为封闭和受保护资源所必需的基础设施。