Stress, Lead, Iron Deficiency and Neurodevelopment

压力、铅、缺铁和神经发育

• 批准号: 7992436
• 负责人: Robert O Wright
• 金额: $ 50.19万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-15 至 2011-12-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7992436
• 关键词: 3 year old; Address; Age-Months; American; Anemia; Animals; Archives; Area Under Curve; Biological; Biological Markers; Birth; Blood; British; Chemicals; Child; Child Development; Chronic; Chronic stress; Cities; Cognitive; Cohort Analysis; Cohort Studies; Communities; Complex; Data; Data Analyses; Development; Dietary Iron; Dose; Effectiveness; Environmental Health; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Feasibility Studies; Funding; Future; Genes; Genotype; Goals; Hemoglobin; Human; Hydrocortisone; Infant; Infant Development; Institutes; Intake; International; Intervention; Investigation; Iron; Iron deficiency anemia; Joints; Laboratories; Lead; Lead Poisoning; Life; Light; Link; Malnutrition; Measures; Mediating; Medical center; Mexico; Modification; Mothers; Nature; Neurotoxins; Outcome; Participant; Pediatrics; Pilot Projects; Poisoning; Predisposition; Pregnancy; Pregnant Women; Prevention; Prevention strategy; Primary Prevention; Psychological Stress; Psychosocial Stress; Public Health; Public Health Schools; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resistance; Salivary; Sample Size; Sampling; Secondary Prevention; Series; Social Environment; Social Sciences; Stress; Testing; Toxic effect; Toxicology; Treatment Protocols; United States National Institutes of Health; Validation; Work; cohort; design; developmental psychology; early childhood; gene environment interaction; health disparity; improved; indexing; interest; lead exposure; maternal stress; molecular marker; neurodevelopment; neurotoxicity; nutrition; prenatal; prospective; response; skills; social; social stress; socioeconomics; stressor; therapy design

Social stressors, iron deficiency anemia, and lead exposure are all environmental risk factors for poor neurodevelopment in young children. All three factors are highly prevalent in poor communities, whether in Mexico or the U.S. There are scant human epidemiologic studies on chronic social stress and human neurodevelopment. In addition, previous studies of child development and neurotoxicants have typically analyzed covariate markers of social stress as independent predictors of neurodevelopment; and thus, only considered social factors as potential confounders in their data analysis. There are biological reasons to believe that stress potentiates the toxicity of iron deficiency anemia and lead poisoning. If so, then understanding this relationship may be the key to designing effective public health interventions designed to improve neurodevelopment and may explain the lack of effectiveness of prevention/treatment regimens for lead poisoning and iron deficiency. A prospective cohort study with a large sample size is needed to address the potential multiplicative effects of combined stress/iron deficiency anemia and combined stress/lead exposure in predicting infant development. This resubmission includes new data from a pilot study of stress-lead/stress-anemia interactions in 120 mother infant pairs conducted since the prior application, which demonstrates study feasibility and evidence for the hypothesized interactions. In this proposal we will measure maternal stress levels, infant iron deficiency anemia and lead exposure in a cohort of mother-infant pairs living in Mexico City and longitudinally measure maternal stress, iron stores, lead exposure, salivary cortisol and neurodevelopment beginning pre-natally and extending 3 years post-partum. This project will determine the independent effect of pre- and post-partum maternal stress in predicting infant development, and the multiplicative joint effects of maternal stress/iron deficiency and maternal stress/lead poisoning in predicting infant development.

社会压力、缺铁性贫血和铅暴露都是贫困人口的环境风险因素。 儿童的神经发育。所有这三个因素在贫困社区都非常普遍， 墨西哥或美国。关于慢性社会压力和人类疾病的人类流行病学研究很少。 神经发育此外，以前对儿童发育和神经毒物的研究通常 分析了社会压力的协变量标志物作为神经发育的独立预测因子;因此，只有 在他们的数据分析中，社会因素被认为是潜在的混杂因素。有生物学上的原因 认为压力会增强缺铁性贫血和铅中毒的毒性。如果是这样，那么 理解这种关系可能是设计有效的公共卫生干预措施的关键， 改善神经发育，并可能解释缺乏有效的预防/治疗方案， 铅中毒和缺铁。需要一项大样本量的前瞻性队列研究来解决 联合应激/缺铁性贫血和联合应激/铅的潜在倍增效应 在预测婴儿发育中的作用。 这份重新提交的报告包括了来自120个国家的一项关于压力-铅/压力-贫血相互作用的初步研究的新数据。 自上次申请以来进行的母婴配对，证明了研究的可行性和证据 假设的相互作用。在这项建议中，我们将测量产妇的压力水平，婴儿铁 一组生活在墨西哥城的母亲-婴儿对的缺铁性贫血和铅暴露， 纵向测量母体压力、铁储备、铅暴露、唾液皮质醇和神经发育 从产前开始，产后3年。这个项目将决定独立效果 产前和产后母亲压力在预测婴儿发育方面的作用，以及 母亲压力/铁缺乏和母亲压力/铅中毒预测婴儿发育。