HEALTHY AGING AND SENILE DEMENTIA

健康老龄化和老年痴呆症

• 批准号: 7841882
• 负责人: JOHN MORRIS
• 金额: $ 241.19万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7841882
• 关键词: HEALTHY; AGING; SENILE; DEMENTIA

DESCRIPTION (provided by applicant): This application is for the 5-year renewal of the program project, Healthy Aging and Senile Dementia (HASD), now in its 25th year. In this renewal, there is a continued focus on the clinical, psychometric, and neuropathologic correlates of dementia of the Alzheimer type (DAT) in comparison with healthy aging with a new thrust addressing preclinical Alzheimer's disease. Five interactive and supportive Cores are proposed: Core A: Administration provides administrative support to all components and assures progress in accomplishing program project goals. Core B: Clinical recruits, enrolls, psychometrically and clinically assesses subjects annually to supply all projects. Core C: Biostatistics oversees data management and provides statistical input to all Cores and projects. Core D: Neuropathology performs postmortem examinations for clinicopathological correlation for all studies and provides appropriate tissue and data to Projects as needed. Core E: Neuroimaging collects structural imaging data on our cohort to visualize change in anatomy associated with cognitive decline. Two new projects replace the current Projects 1 and 4, which have been completed. The new Project 1 ("Preclinical AD predicts poststroke dementia" JC Morris) examines the relationship between the presence of amyloid in the brain (as measured by PET PIB) at time of stroke to the later development of dementia. The new Project 4 ("Sequence variation in genes for biomarker proteins and age at onset of Alzheimer's Disease" AM Goate) uses CSF proteins as intermediate traits, or endophenotypes, to identify novel genetic risk factors for late onset DAT. Two current projects will continue in this application to extend their findings and explore new initiatives. Project 2 ("Antecedent biomarkers of AD in CSF and plasma" DM Holtzman) examines whether markers in the CSF and plasma proteome can be combined to develop a more accurate determination of dementia risk in cognitively normal elderly individuals. Project 3 ("Markers for DAT: Control, Variability and Personality," D Balota) will develop cognitive markers as early indicators of DAT. Together, these projects and their supporting cores will focus on preclinical DAT in comparison with healthy brain aging and address the issue of detecting preclinical disease.

说明（由申请人提供）：本申请为健康老龄化与老年痴呆症项目（HASD）续期5年，该项目已进入第25个年头。在这一更新中，继续关注阿尔茨海默氏型痴呆（DAT）的临床、心理测量学和神经病理学相关性，并将其与健康衰老进行比较，并提出新的重点，以解决临床前阿尔茨海默氏病。核心A：行政管理为所有组成部分提供行政支持，并确保完成项目目标的进展。核心B：临床招募，登记，心理测量和临床评估对象，每年提供所有项目。核心C：生物统计学监督数据管理，并为所有核心和项目提供统计输入。核心D：神经病理学为所有研究的临床病理相关性进行尸检，并根据需要为项目提供适当的组织和数据。核心E：神经成像收集我们队列的结构成像数据，以可视化与认知能力下降相关的解剖变化。两个新项目取代目前已经完成的项目1和项目4。新项目1（“临床前AD预测中风后痴呆”JC Morris）研究了中风时大脑中淀粉样蛋白的存在（通过PET PIB测量）与痴呆后期发展之间的关系。新的项目4（“生物标记蛋白基因序列变异和阿尔茨海默病发病年龄”）使用CSF蛋白作为中间性状或内表型，以确定迟发性DAT的新遗传风险因素。目前的两个项目将在本应用程序中继续进行，以扩展他们的发现并探索新的举措。项目2（“脑脊液和血浆中AD的先行生物标志物”DM Holtzman）检查脑脊液和血浆蛋白质组中的标志物是否可以结合起来，以更准确地确定认知正常老年人的痴呆风险。项目3（“数据数据的标记：控制、可变性和个性”，D Balota）将开发认知标记作为数据数据的早期指标。总之，这些项目及其支持核心将集中于临床前数据与健康大脑衰老的比较，并解决检测临床前疾病的问题。