Healthy Aging and Senile Dementia

健康老龄化和老年痴呆症

• 批准号: 10622476
• 负责人: JOHN MORRIS
• 金额: $ 370.51万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622476
• 关键词: Address; Affect; African American; African American population; Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-Protein; Autopsy; Axon; Biological; Biological Markers; Biological Specimen Banks; Biometry; Blood; Brain; Brain imaging; Budgets; Cellular Phone; Cerebrospinal Fluid; Cerebrum; Clinical; Clinical assessments; Cognitive; Collaborations; Consent; DNA; Data; Deposition; Development; Disease Progression; Elderly; Enrollment; Functional disorder; Funding; Genetic; Genetic study; Goals; Home; Image; Individual; Infrastructure; Injury; Laboratories; Leadership; Longitudinal cohort; Magnetic Resonance Imaging; Magnetism; Measurement; Measures; Methods; Modality; Neuronal Dysfunction; Not Hispanic or Latino; Participant; Phenotype; Positron-Emission Tomography; Predictive Factor; Productivity; Program Research Project Grants; Protocols documentation; Research; Role; Senile Plaques; Senile dementia; Signal Transduction; Sleep; Structure; Synapses; System; Talents; cognitive function; cognitive performance; cognitive testing; cohort; experience; genetic architecture; genetic variant; healthy aging; hypocretin; imaging biomarker; imaging study; innovation; molecular marker; neuropathology; novel; pre-clinical; prognostic; progression marker; prospective; racial disparity; radioligand; resilience; smartphone application; structural imaging; supportive environment; tau Proteins; theranostics

Overall Project Summary The over-arching goal of the Healthy Aging and Senile Dementia (HASD) study is to determine the factors that signal the imminent development of symptomatic Alzheimer disease (AD) in cognitively normal older adults. In pursuing this goal, HASD also will examine whether these predictive factors differ between African Americans and non-Hispanic whites, are influenced by sleep, or might be offset by genetic variants that protect against developing symptomatic AD. Finally, HASD will evaluate a novel method of assessing cognitive performance in naturalistic settings via a smartphone application. To accomplish these goals, HASD will assess and follow a richly phenotyped cohort that includes both cognitively normal older adults (~75%) and those with early-stage symptomatic AD (~25%). The longitudinal assessment protocol includes standard and novel clinical and cognitive measures, a six-day in-home sleep study, magnetic structural imaging studies of the brain, positron emission tomography studies of the brain to reveal the cerebral hallmarks of AD, amyloid-beta plaques and tau deposition, and examination of blood for genetic studies and of cerebrospinal fluid for levels of amyloid-beta and tau. Five Cores (Administration, Clinical, Biostatistics, Neuropathology [includes the Biofluids Laboratory], and Imaging) will support four Projects that carry out the scientific aims of HASD: Project 1: “Characterization of Molecular Biomarker Profiles of AD throughout its Pathobiological Continuum” Project 2: “Sleep and Orexin: Potential Markers of Progression from Preclinical to Mildly Symptomatic Alzheimer Disease” Project 3: “Dissecting the Genetic Architecture of Resilience” Project 4: “Smartphone-Based `Burst' Cognitive Assessments”

整体项目总结

项目成果

White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease

与阿尔茨海默病相关的白质高信号纵向形态测量分析

• DOI: 10.1002/alz.13377
• 发表时间: 2023
• 期刊: Alzheimer's & Dementia
• 作者: Strain, Jeremy Fuller;Phuah, Chia‐Ling;Adeyemo, Babatunde;Cheng, Kathleen;Womack, Kyle B.;McCarthy, John;Goyal, Manu;Chen, Yasheng;Sotiras, Aristeidis;An, Hongyu
• 通讯作者: An, Hongyu

Relationship between late-life hypertension, blood pressure, and Alzheimer's disease.

• DOI: 10.1177/1533317511421779
• 发表时间: 2011-09
• 期刊: American journal of Alzheimer's disease and other dementias
• 作者: Yang YH;Roe CM;Morris JC
• 通讯作者: Morris JC

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• DOI: 10.1002/art.40923
• 发表时间: 2019
• 期刊: Arthritis & rheumatology (Hoboken, N.J.)
• 作者: Kim,AlfredHJ;Strand,Vibeke;Atkinson,JohnP
• 通讯作者: Atkinson,JohnP

Signed graph representation learning for functional-to-structural brain network mapping

• DOI: 10.1016/j.media.2022.102674
• 发表时间: 2022-11
• 期刊: Medical image analysis
• 影响因子: 10.9
• 作者: Haoteng Tang;Lei Guo;Xiyao Fu;Yalin Wang;S. Mackin;O. Ajilore;A. Leow;Paul M. Thompson;Heng Huang;L. Zhan

Focal and nonfocal prospective memory performance in very mild dementia: a signature decline.

• DOI: 10.1037/a0021682
• 发表时间: 2011-05
• 期刊: NEUROPSYCHOLOGY
• 影响因子: 2.4
• 作者: McDaniel, Mark A.;Shelton, Jill Talley;Breneiser, Jennifer E.;Moynan, Sarah;Balota, David A.
• 通讯作者: Balota, David A.