Vanderbilt Mouse Metabolic Phenotyping Center

范德比尔特小鼠代谢表型中心

• 批准号: 8708031
• 负责人: DAVID H WASSERMAN
• 金额: $ 93.6万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708031
• 关键词: Animals; Area; Back; Cardiovascular Diseases; Cardiovascular system; Charge; Commit; Communities; Complications of Diabetes Mellitus; Conscious; Development; Diabetes Mellitus; Diabetic mouse; Disease; Education and Outreach; Ensure; Faculty; Functional disorder; Guidelines; Health; Hormones; Imaging Techniques; Insulin; Knowledge; Leadership; Medical Research; Metabolic; Metabolism; Methodology; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Organ; Phenotype; Policies; Procedures; Recovery; Research; Research Infrastructure; Resources; Sampling; Scientist; Services; Social Welfare; Technology; Testing; United States National Institutes of Health; Work; biological research; cost; data management; energy balance; insight; islet; meetings; programs; research study

DESCRIPTION (provided by applicant): The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and biological research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The Administrative Core provides scientific, financial, and administrative leadership. This Core also oversees service requests, data management, and tracks mice studied at the VMMPC. The Administrative Core is also responsible for the VMMPC educational program. The Animal Health and Welfare Core evaluates mice submitted to the VMMPC, oversees the health and welfare of the colony, and ensures compliance with regulatory bodies and MMPC guidelines. Services provided by the Metabolic Pathophysiology Core (MPC) emphasize methodology to study energy balance, insulin action, hormone secretion, and metabolism in the conscious, unstressed mouse. The MPC also has the capacity to assess organ or islet function in isolation and can apply state-of-the-art imaging techniques. The Cardiovascular Pathophysiology and Complications Core has a range of tests to study cardiovascular disease and other complications of diabetes. The Analytical Resources Core receives samples generated from VMMPC testing and from experiments conducted outside the VMMPC. Analyses performed by this core are specific to the mouse and are scaled to accommodate small sample volumes. The VMMPC exists because of the insight of leadership at the NIDDK, a generous commitment of space and resources from VUMC, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is the people that comprise it. This NIDDK experiment in mouse phenotyping requires a faculty that is willing to make technology that is part of their research lifeline available to the scientific community for no more than the recovery of costs and the knowledge that they are working for a greater good. It requires a staff that is so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them.

描述（由申请人提供）：范德比尔特小鼠代谢表型中心 (VMMPC) 成立于 2001 年，旨在通过为科学界提供糖尿病、糖尿病并发症和肥胖小鼠模型的标准化、高质量表型服务来推进医学和生物学研究。 VMMPC 由五个核心组成。行政核心提供科学、财务和行政领导。该核心还负责监督服务请求、数据管理并跟踪在 VMMPC 上研究的小鼠。行政核心还负责 VMMPC 教育计划。动物健康和福利核心评估提交给 VMMPC 的小鼠，监督群体的健康和福利，并确保遵守监管机构和 MMPC 指南。代谢病理生理学核心 (MPC) 提供的服务强调研究有意识、无压力的小鼠的能量平衡、胰岛素作用、激素分泌和新陈代谢的方法。 MPC 还能够单独评估器官或胰岛功能，并可以应用最先进的成像技术。心血管病理生理学和并发症核心有一系列测试来研究心血管疾病和其他糖尿病并发症。分析资源核心接收从 VMMPC 测试和在 VMMPC 外部进行的实验生成的样本。该核心执行的分析是针对小鼠的，并进行缩放以适应小样本量。 VMMPC 的存在得益于 NIDDK 领导层的洞察力、VUMC 慷慨的空间和资源承诺以及精心设计的基础设施。但 VMMPC 能够发挥出色作用的主要原因在于它的组成人员。 NIDDK 的小鼠表型实验需要教师愿意将作为其研究生命线一部分的技术提供给科学界，而仅仅是为了收回成本和了解他们正在为更大的利益而努力。它需要一支技术精湛且忠诚的工作人员，让科学家们愿意将他们的小鼠、他们的研究生命线托付给他们。