Real-time cardiovascular MRI and co-registration technical development

实时心血管MRI及联合配准技术开发

• 批准号: 9157375
• 负责人: Robert J Lederman
• 金额: $ 66.74万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9157375
• 关键词: Adult; Agreement; Algorithms; Cardiovascular system; Caring; Catheterization; Catheters; Child; Collaborations; Computer software; Data; Defibrillators; Development; Devices; Diagnostic radiologic examination; Environment; Heating; Hour; Image; Imagery; Industry; Magnetic Resonance Imaging; Medical; Monitor; Motion; Pacemakers; Patient Care; Patients; Physiological; Process; Research Personnel; Roentgen Rays; Safety; Stream; System; Techniques; Technology; Telemetry; Time; Translations; United States National Institutes of Health; Work; base; bioimaging; clinical practice; cloud based; computing resources; hemodynamics; imaging platform; implantable device; open source; parallel computer; reconstruction; research and development; research study; tool

During the past year we have continued enhancement of imaging platforms to guide cardiovascular catheter based treatments. These have included co-registered MRI with conventional X-ray, as well as standalone real-time MRI. We are working closely with industry, through a Collaborative Research and Development Agreement, to introduce motion-corrected roadmaps into clinical practice. We continue to enhance a system for safe patient hemodynamic monitoring and recording during interventional MRI experiments and during transfer between X-ray and MRI. We are applying this work towards adults and children undergoing MRI catheterization, and we are working internally and with industry to enhance this technology. Our collaborator Michael S. Hansen has used inexpensive parallel computing resources afforded by game-oriented graphics processing units to accelerate reconstruction of computationally-intensive MRI data. We have successfully integrated non-Cartesian parallel imaging in an interactive acquisition and reconstruction setup and demonstrated that real-time reconstruction and visualization is possible for relatively complicated reconstruction algorithms. This has been integrated with the scanner software to allow seamless combination with other sequence components. This has been disseminated as an open-source image-streaming framework that has become very popular with extensive applications in biomedical imaging. Further enhancements this year allow us to obtain high-fidelity images in patients during MRI catheterization using cloud-based computation in seconds that might otherwise take as long as hours, for real-time care of patients. We are developing techniques of MRI that minimize heating of metallic devices, that might allow MRI catheterization using tools previously considered unsafe, or that might enhance the safety of MRI in patients who have implanted devices like pacemakers and defibrillators. We are working closely with industry to transfer our developments into commercial tools that can be used widely in medical care throughout the world.

在过去的一年中，我们继续加强成像平台，以指导心血管导管治疗。其中包括与传统x射线联合注册的MRI，以及独立的实时MRI。