Alzheimer Disease Research Center

描述(由申请人提供)：南加州大学阿尔茨海默病研究中心(ADRC)专注于减少不同人群中阿尔茨海默病和血管对认知障碍的贡献。ADRC从神经生物学和衰老心理学的广泛背景下看待大脑健康，阿尔茨海默病(AD)和脑血管疾病(CVD)是病理性认知能力下降的两个主要原因。早在“转化性”研究流行之前，我们就已经建立了一个跨学科团队，将基础科学与临床试验联系起来。本次续展申请包括三个加强翻译研究的项目。我们的人口包括一项对参加长滩纵向研究(LBLS)的高加索人进行的为期15年的前瞻性研究，一项针对社区洛杉矶拉丁裔眼科研究(LALES)的为期10年的拉美裔前瞻性研究，以及一项新资助的、基于社区的华裔美国人眼科研究(CHES)。几个附属的队列包括老龄化大脑计划项目(PLChui)和黄体酮与大脑老龄化和阿尔茨海默病(PI：R.Brinton)。 在接下来的五年里，我们将专注于以下总体目标：1)澄清AD和CVD之间的病理和表型相互作用；2)增加从LALES、CHS和周围社区招募和保留少数族裔受试者；3)促进南加州大学记忆和衰老方面的临床试验和翻译研究；4)继续积极参与国家倡议，包括国家阿尔茨海默病协调中心(NACC)、阿尔茨海默病合作研究(ADCS)、阿尔茨海默病神经成像倡议(ADNI)和基因组广泛关联研究(GWAS)。ADRC包括6个核心(行政、数据、临床、教育、病理和成像)和3个项目：Zelinski(成年后期认知变化课程)、Brinton/Pike(防止阿尔茨海默病病理的新型NeuroSERM和NeuroSARM)和郑(华裔美国社区的认知障碍)。

DESCRIPTION (provided by applicant): The Alzheimer Disease Research Center (ADRC) at the University of Southern California (USC) focuses on Reducing Alzheimer and Vascular Contributions to Cognitive Impairment in Diverse Populations. The ADRC views brain health in the broad context of the neurobiology and psychology of aging, with Alzheimer Disease (AD) and cerebrovascular disease (CVD) as the two major causes of pathological cognitive decline. We have built an interdisciplinary team to bridge basic science to clinical trials, well before the term "translational" research became popular. This renewal application includes three projects which strengthen translational research. Our populations include a 15-year prospective study of Caucasians enrolled in the Long Beach Longitudinal Study (LBLS), a 10-year prospective study of Hispanics in the community-based Los Angeles Latino Eye Study (LALES) and a newly funded, community-based Chinese American Eye Study (CHES). Several affiliated cohorts include the Aging Brain Program Project (PLChui) and the Progesterone and Brain Aging and Alzheimer Disease (PI: R. Brinton). During the next five years, we will focus on the following overarching goals: 1) Clarify the pathological and phenotypic interactions between AD and CVD, 2) Increase recruitment and retention of minority subjects from LALES, CHES, and the surrounding neighborhood, 3) Promote clinical trials and translational research in memory and aging at USC, and 4) Continue active participation in national initiatives, including National Alzheimer Coordinating Center (NACC), Alzheimer Disease Cooperative Study (ADCS), Alzheimer Disease Neuroimaging Initiative (ADNI), and Genome Wide Association Study (GWAS). The ADRC comprise 6 Cores (Administration, Data, Clinical, Education, Pathology, and Imaging) and 3 Projects: Zelinski (Course of Cognitive Change in Late Adulthood), Brinton/Pike (Novel NeuroSERMs and NeuroSARMs for protection against Alzheimer pathology), and Zheng (Cognitive Impairment in a Chinese American Community).