Developmental Core

抽象发展核心 沃兹沃斯中心人类健康暴露分析资源(WC-HHEAR)的总体目标 发展核心(开发核心)是利用现有的资源、专业知识和能力， 沃兹沃斯将开发和验证量化分析的新方法和分析方法 对生物群落中新兴化学物质的测量，即突破人类的界限 生物监测。Kannan博士和Parsons博士是这项提案的MPI，他们是各自领域的领导者 拥有700多种出版物。在过去的二十年里，他们一直在建造人类 沃兹沃斯的生物监测计划--在帕森斯博士的微量元素实验室(Trel)和在Dr。 卡南的人体有机物生物监测实验室(Hobl)。这些努力包括组装目前的 分析能力；在人体组织和液体中发现新出现的化学物质；开发和 验证新的分析方法；支持推进人类健康研究和 环境。Hobl和Trel都有大量的分析和功能列表，这些都是 《汇辑》承诺支持WC-HHEAR目标分析资源(TAR)。其中一位开发人员。 CORE的功能将是改进现有的方法，需要更少的分析样本量，做 用有限的样本量获得更多，提高检测极限，增加样品吞吐量，减少 成本，并在最先进的技术可用时利用它们。例如，建议的 戴夫。CORE将研究可用于多个有机类别的提取 使用基于以下技术的新一代技术来提高对痕量元素的检测能力 无机串联质谱仪。开发人员将开发新的功能。核心和经过验证的 按照国际标准进行单实验室方法验证。开发人员。核心将构建 利用其在非传统矩阵方面的现有专业知识，在更多矩阵类型中提供更多目标，并将 响应HHEAR-受未确定目标的资源中的发现、来自 HHEAR客户，或HHEAR项目办公室的建议。将这些改进转移到 目前的方法将由WC-HHEAR行政核心促进，其中整合了关键工作人员 既有焦油又有Dev。核心。只有通过上述进展，高质量、 定量的、暴露的研究可以蓬勃发展。

ABSTRACT – DEVELOPMENTAL CORE The overall goal of the Wadsworth Center’s Human Health Exposure Analysis Resource (WC-HHEAR) Developmental Core (Dev. Core) is to capitalize on the existing resources, expertise, and capacity at Wadsworth to develop and validate novel methods and analytical approaches for quantitative measurements of emerging chemicals in biospecimens, i.e., pushing the boundaries of human biomonitoring. Drs. Kannan and Parsons, the MPIs on this proposal, are leaders in their respective fields with more than 700 combined publications. They have spent the last two decades building the human biomonitoring program at Wadsworth – in Dr. Parsons’ Trace Elements Laboratory (TREL) and in Dr. Kannan’s Human Organics Biomonitoring Lab (HOBL). These efforts include assembling the current analytical capability; discovering emerging chemicals in human tissues and fluids; developing and validating new methods of analysis; and supporting the advancement of human health studies and the environment. Both HOBL and TREL have expansive lists of assays and capabilities that are part of the repertoire committed to support the WC-HHEAR targeted analysis resource (TAR). One of the Dev. Core’s functions will be to improve existing methods, requiring less sample volume for analysis, doing more with a limited amount of sample, improving detection limits, increasing sample throughput, reducing costs, and leveraging state-of-the-art technologies as they become available. For example, the proposed Dev. Core will investigate extractions that can be implemented for use on multiple classes of organic chemicals and improving detectability for trace elements using a new generation of technology based on inorganic tandem mass spectrometry. New capabilities will be developed in the Dev. Core and validated according to the international standards for single-laboratory method validation. The Dev. Core will build on its existing expertise with non-traditional matrices to offer more targets in more matrix types and will respond to HHEAR – driven by either discoveries in the untargeted resource, increased demand from HHEAR clients, or suggestions from the HHEAR program office. The transfer of these improvements to current methods will be facilitated by the WC-HHEAR administrative core, where key staff are integrated into both the TAR and Dev. Core. It is only through the progress outlined above that high-quality, quantitative, exposome research can flourish.