Translational Research

项目总结(见说明)： 自翻译研究共享资源成立以来，其使命一直是为KCC研究人员正在使用的人类肿瘤组织和实验动物模型组织提供组织处理、载玻片准备、组织化学染色和免疫组织化学染色。这一共享资源还提供了人类肿瘤组织的采购、储存和分配，以促进转译研究。自2007年以来，组织银行家一直使用caBlG caTIssue生物标本管理应用程序来输入临床和病理标本注释，以及跟踪标本存储和分发。这个生物标本数据库集成了对7个校园标本收藏的访问，这些标本收集了来自17万个人的约44万个标本。此外，转译研究共享资源提供组织微阵列构建服务，使用来自资源肿瘤/组织库的石蜡档案材料。用于分子分析的不同细胞和组织类型的激光显微切割可以在资源的激光显微切割系统上执行。对于所有功能， 由翻译研究共享资源提供，工作人员可以为KCC调查人员提供技术支持和病理学专业知识。2008至2011年间，来自KCC所有项目的23名首席调查人员受益于这一共享资源。

PROJECT SUMMARY (See instructions): Since the inception of the Translational Research Shared Resource its mission has been to provide tissue processing, slide preparation, histochemical staining, and immunohistochemical staining for human neoplastic tissue and experimental animal model tissue being utilized by KCC researchers. This shared resource has also provided procurement, banking and distribution of human neoplastic tissue in order to facilitate translational research. The caBlG caTissue biospecimen management application has been used by tissue bankers since 2007 to enter clinical and pathogical specimen annotation, as well as track specimen storage and distribution. This biospecimen database integrates access to 7 campus specimen collections having about 440,000 specimens from 170,000 individuals. In addition, the Translational Research Shared Resource provides tissue microarrays construction service with paraffin archive material from the resource tumor/tissue bank. Laser microdissection of distinct cell and tissue types for molecular analysis can be performed on the resource's Laser Microdissection system. For all of the capabilities offered by the Translational Research Shared Resource, staff is available to provide technical support and pathology expertise to KCC investigators. Between 2008 and 2011 23 principal investigators from all programs of the KCC benefited from this shared resource.