ABCD-USA Consortium: Coordinating Center

 描述（由申请人提供）：ABCD-USA联盟提出了一项研究，旨在允许我们的研究人员和科学界回答有关物质使用（SU）对青少年行为和大脑发育影响的重要问题。我们已经组建了一个研究团队，他们具有无与伦比的青年研究经验，以及青少年SU，儿童和青少年发展，发育精神病理学，纵向多部位成像，发育神经成像和认知神经科学，遗传学和成像遗传学，生物测定，流行病学，调查研究，生物信息学和移动的评估技术的特定专业知识。我们建议在全国范围内对10，000名9-10奥尔兹进行研究，这些儿童在21个地点组织成11个中心（29%的美国人口居住在我们地理分布的地点50英里内），独特地，可以提供具有全国代表性的样本和大型双胞胎样本，这些样本可以帮助区分与SU和大脑发育相关的环境，社会文化和遗传因素。我们通过专业调查公司设计的招聘策略（具有监测未来的经验）确保凝聚力和标准化;标准化的环境，神经认知和心理健康评估，使用协调的人类连接组项目程序进行扫描仪的MRI评估，以及实时质量控制的计算机化数据收集。开发定制的评估将具有稳定的敏感性和结构效度在整个儿童和青少年，最大限度地减少参与者的负担，捕捉甚至微妙的变化，在SU，心理健康，神经认知，发展和环境，并采用新的生物测定和被动数据收集从移动的设备。保留计划建立在我们调查人员的经验基础上，以确保成功。本申请描述了ABCD-美国协调中心（CC），该中心将：为联合体提供全面的行政和后勤支持以及科学整合;建立并实施核心方案、参与者招募和保留以及数据质量控制程序;为标准化人员提供初始和持续培训;真实的监控队列属性、招募和保留实践、数据质量和联盟范围内的一致性，并监控基准和时间表的进度。CC将确保遵守研究的道德标准和文化敏感性，并制定和实施争议解决，内部和外部数据共享和出版的政策。CC为联合体、指导委员会、科学咨询委员会和工作组的会议和电话会议以及教育、科学、外联和传播活动组织并提供后勤支持。从设计上看，气候变化进程在解决问题和纳入新出现的科学机会方面是灵活的。我们通过网络向公众提供透明的研究更新，以及一个管理良好和充分注释的数据库，以便及时共享。重要的是，我们为药物滥用领域的发展科学家提供培训和指导。

 DESCRIPTION (provided by applicant): The ABCD-USA Consortium proposes a study designed to permit our investigators and the scientific community to answer important questions about the effects of substance use (SU) on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with youth, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging and cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a nationwide study of 10,000 9-10 year olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development. We ensure cohesion and standardization with a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across childhood and adolescence, minimize participant burden, capture even subtle changes in SU, mental health, neurocognition, development, and environment, and employ novel bioassays and passive data collection from mobile devices. The retention plan builds on the experience of our investigators to ensure success. This application describes the ABCD-USA Coordinating Center (CC) which will: provide overall administrative and logistical support and scientific integration fr the consortium; establish and implement procedures for core protocols, participant recruitment and retention, and data quality control; provide initial and ongoing training of personnel for standardization; monitor cohort attributes, recruiting and retention practices, data quality, and consortium-wide consistency in real time, and monitor progress toward benchmarks and timelines. CC will ensure adherence to ethical standards and cultural sensitivity of research, and establish and implement policies for dispute resolution, internal and external data sharing, and publication. CC organizes and provides logistical support for meetings and teleconferences of the consortium, steering committee, scientific advisory board and workgroups as well as for educational, scientific, outreach, and dissemination events. By design, CC processes are flexible for problem resolution and incorporation of emerging scientific opportunities. We provide transparent study updates to the public via the web, and a well-managed and fully annotated repository of data for timely sharing. Importantly, we provide training and mentoring to developing scientists in the drug abuse area.