National Consortium on Alcohol and Neurodevelopment in Adolescence: Admin

项目摘要 酒精使用和酒精相关伤害的风险在青少年和年轻人中很普遍（即，12岁- 这也是人类大脑发育的关键时期。根据RFA-AA-17-004，本申请 建议国家酒精和神经发育联盟的行政资源（AR）， 青少年第二阶段（NCANDA-2），位于加州大学圣地亚哥分校。联盟的首要目标是 确定青少年和年轻人大量饮酒的预测因素和影响， 青少年的人口统计学代表性样本。该联盟旨在协同多种因素 每个研究中心研究者的科学专业知识和研究经验。该联盟反映了七个 应用程序：NCANDA -管理资源（UCSD）和NCANDA -数据分析资源（SRI），以及 位于俄勒冈州健康科学杜克大学（杜克）的五个跨国研究项目地点 大学（OHSU），匹兹堡大学（皮特），SRI国际（SRI）和加州大学圣地亚哥分校（UCSD）。 招募年龄在12岁至21岁之间的五个地点，高风险增强社区样本的831名受试者 完成了一项基线评估和三项年度后续评估， 设计NCANDA-2将继续跟踪这一队列，通过典型的一生饮酒高峰年龄，使用 多模式神经成像、认知测试、行为访谈、生物样本收集和技术- 加强对自然环境的评估。对酒精后果的审查将集中在 在青春期活跃发育的大脑区域的结构和功能成熟， 自我调节和奖励反应，似乎容易受到酒精的神经毒性影响。五个目标 将对RFA中规定的目标进行系统测试，重点是青少年物质使用， 神经成熟轨迹每个研究项目研究中心与另一个研究中心合作， 目标。加州大学圣地亚哥分校，OHSU和杜克正在研究超过4周的监测酗酒者的大脑恢复情况。 禁欲皮特和SRI合作研究酗酒，睡眠特征和大脑之间的关系 发展我们正在研究大量饮酒对抑制功能障碍的影响， 这介导的认知表现，使用纵向功能磁共振成像连接分析在反眼跳 (Pitt，杜克）和Stroop匹配样本（SRI和UCSD）任务。随着额外的发展， 根据本次更新提供的纵向数据，我们将确定酒精暴露对 青少年大脑的发展轨迹，并确定预先存在的心理生物学 脆弱性，可能会使青少年或年轻人处于酒精使用障碍或其他 不良生活后果。

PROJECT SUMMARY Alcohol use and risk for alcohol-related harm is prevalent in adolescence and young adulthood (i.e., age 12- 25), and this is also a critical time in human brain development. In response to RFA-AA-17-004, this application proposes the Administrative Resource (AR) of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2), located at UC San Diego. The overarching consortium goals are to determine the predictors and effects of heavy alcohol use in adolescence and young adulthood in a demographically representative sample of adolescents. This consortium was designed to synergize the diverse scientific expertise and research experience of the investigators at each site. This consortium reflects seven applications: NCANDA - Administrative Resource (UCSD) and NCANDA - Data Analysis Resource (SRI), and five cross-national Research Project Sites, located at Duke University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International (SRI), and UC San Diego (UCSD). Recruited at ages 12 through 21 across the five sites, a high-risk enhanced community sample of 831 subjects completed a baseline assessment and three annual follow-up assessments in an accelerated longitudinal design. NCANDA-2 will continue to follow this cohort through the typical age of lifetime peak drinking, using multimodal neuroimaging, cognitive testing, behavioral interviews, biospecimen collection, and technology- enhanced assessment in the natural environment. Examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in self-regulation and reward response, and appear vulnerable to neurotoxic effects of alcohol. Five aims specified in the RFA will be systematically tested with a focus on adolescent substance use and neuromaturational trajectories. Each Research Project Site collaborates with another site on 1-2 additional aims. UCSD, OHSU, and Duke are examining brain recovery in heavy drinkers over 4 weeks of monitored abstinence. Pitt and SRI collaborate to study relations between heavy drinking, sleep characteristics, and brain development. We are examining the influence of heavy drinking on inhibitory dysfunction and the extent to which this mediates cognitive performance, using longitudinal fMRI connectivity analysis during anti-saccade (Pitt, Duke) and Stroop match-to-sample (SRI and UCSD) tasks. With the additional development-specific longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent or young adult at elevated risk for an alcohol use disorder or other adverse life outcome.