National Consortium on Alcohol and NeuroDevelopment in Adolescence: Admin

描述（由申请人提供）：作为对RFA-AA-12-006的回应，本申请提出了位于加州大学圣地亚哥分校的全国酒精和青少年神经发育联盟（n - canada）的行政组成部分，以确定酒精使用对青少年大脑发育的影响。该联盟旨在提供具有全国代表性的青少年样本，并将不同的科学专业知识和研究经验与每个地点的研究人员所代表的青少年结合起来。因此，以下申请应联合考虑：n -加拿大：行政部分，UCSD (PI: Sandra Brown PhD (Contact), Susan Tapert PhD) n -加拿大：数据部分，SRI （PI: Adolf Pfefferbaum， M.D.）n -加拿大：杜克大学（PI: Michael DeBellis， M.D.）n -加拿大：匹兹堡（PI: Duncan Clark, phd， M.D.）n - canada: SRI （PI: Ian Colrain，博士（Contact）和Fiona Baker，博士）n - canada: UCSD （PI: Susan Tapert，博士）招募了年龄在12到21岁之间的680名高风险增强社区样本，他们将完成基线评估，然后在加速纵向设计中进行每年三次的随访评估。在每次就诊时，将测量多模态MRI方案、综合神经心理学电池、酒精使用和相关问题的评估，以及其他物质介入、精神健康症状和其他风险因素。脑成像使用最先进的高分辨率结构MRI （sMRI）、扩散张量成像（DTI）、静息状态MRI （rsMRI）和抗扫视或Stroop功能MRI任务来利用当地的专业知识。对酒精后果的检查将集中在青春期积极发育的大脑区域的结构和功能成熟上，这些区域涉及心理调节，对奖励作出反应，并被认为容易受到有毒酒精的影响。将系统地测试RFA中指定的五个目标，重点是青少年物质使用和神经成熟轨迹。四个研究组成部分中的每一个都将与另一个站点合作实现另外两个目标。在风险和基线大脑特征的背景下进行检查，我们将确定酒精暴露对青少年人类大脑发育轨迹的影响，并确定可能使青少年面临更大酒精使用障碍风险的先前存在的心理生物学脆弱性。

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the Administrative Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA), located at UCSD, to determine the effects of alcohol use on the developing adolescent brain. This consortium was designed to provide a nationally representative sample of adolescents and to integrate the diverse scientific expertise and research experience with youth represented by researchers at each site. As such, the following applications should be considered jointly: N-CANDA: Administrative Component, UCSD (PI: Sandra Brown PhD (Contact), Susan Tapert PhD) N-CANDA: Data Component, SRI (PI: Adolf Pfefferbaum, M.D.) N-CANDA: Duke (PI: Michael DeBellis, M.D.) N-CANDA: Pittsburgh (PI: Duncan Clark, Ph.D., M.D.) N-CANDA: SRI (PIs: Ian Colrain, Ph.D. (Contact) and Fiona Baker, Ph.D.) N-CANDA: UCSD (PI: Susan Tapert, Ph.D.) Recruited at ages 12 through 21, a high-risk enhanced community sample of 680 subjects will complete a baseline assessment then undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal MRI protocol, comprehensive neuropsychological battery, and assessment of alcohol use and related problems, along with other substance involvement, mental health symptoms, and other risk factors, will be measured. Brain imaging uses state-of-the-art high-resolution structural MRI (sMRI), diffusion tensor imaging (DTI), resting state MRI (rsMRI), and an anti-saccade or Stroop functional MRI task to capitalize on local expertise. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to toxic alcohol effects. Five aims specified in the RFA will be systematically tested with a focus on adolescent substance use and neuromaturational trajectories. Each of the four Research Components will collaborate with another site on two additional aims. Examined in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at greater risk for an alcohol use disorder.