The intersection between hedgehog and notch signalling in medulloblastoma.

髓母细胞瘤中刺猬信号和缺口信号之间的交叉点。

• 批准号: nhmrc : 631650
• 负责人: Prof Brandon Wainwright
• 金额: $ 41.38万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intersection-hedgehog-notch-signalling-medulloblastoma/96562
• 关键词: intersection; between; hedgehog; notch; signalling

Brain tumours are the second most common malignancy of childhood and the leading cause of cancer related death and disability in children. Medulloblastoma is the most frequent malignant childhood brain tumour, arising in the cerebellum. This application looks at the relationship between two genetic pathways responsible for medulloblastoma which are also drug targets. Understanding this interaction will lead to better treatment options for the disease.

脑肿瘤是儿童时期第二常见的恶性肿瘤，也是儿童癌症相关死亡和残疾的主要原因。髓母细胞瘤是最常见的恶性儿童脑肿瘤，起源于小脑。该应用着眼于导致髓母细胞瘤的两种遗传途径之间的关系，这两种途径也是药物靶点。了解这种相互作用将为该疾病带来更好的治疗选择。