The intersection between hedgehog and notch signalling in medulloblastoma.
The intersection between hedgehog and notch signalling in medulloblastoma.
批准号:
nhmrc : 631650
负责人:
Prof Brandon Wainwright
金额:
$41.38万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Brain tumours are the second most common malignancy of childhood and the leading cause of cancer related death and disability in children. Medulloblastoma is the most frequent malignant childhood brain tumour, arising in the cerebellum. This application looks at the relationship between two genetic pathways responsible for medulloblastoma which are also drug targets. Understanding this interaction will lead to better treatment options for the disease.
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Identification of genes causing medulloblastoma by transposon mutagenesis.
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批准号:nhmrc : 1034941
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项目类别:Project Grants
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资助金额:$41.47万
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财政年份:2012
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负责人:Prof Brandon Wainwright
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依托单位:
Molecular genetics of the host response defect in cystic fibrosis
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批准号:nhmrc : 401724
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项目类别:NHMRC Project Grants
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资助金额:$37.65万
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财政年份:2007
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负责人:Prof Brandon Wainwright
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依托单位:
The role of Patched/Hedgehog signalling in common human cancer.
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批准号:nhmrc : 301198
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项目类别:NHMRC Project Grants
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资助金额:$33.06万
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财政年份:2004
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负责人:Prof Brandon Wainwright
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依托单位:
Molecular genetics of cystic fibrosis
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批准号:nhmrc : 252906
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项目类别:NHMRC Project Grants
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资助金额:$39.88万
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财政年份:2003
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负责人:Prof Brandon Wainwright
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依托单位:
The downstream targets of Patched/Hedgehog signalling.
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批准号:nhmrc : 143072
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项目类别:NHMRC Project Grants
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资助金额:$28.21万
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财政年份:2001
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负责人:Prof Brandon Wainwright
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依托单位:
Conditional knockout of the murine patched gene for the study of skin differentiation and cancer.
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批准号:nhmrc : 143073
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项目类别:NHMRC Project Grants
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资助金额:$28.24万
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财政年份:2001
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负责人:Prof Brandon Wainwright
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依托单位:
Genes controlling the development of lung disease in normal and cystic fibrosis mice.
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批准号:nhmrc : 102523
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项目类别:NHMRC Project Grants
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资助金额:$24.18万
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财政年份:2001
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负责人:Prof Brandon Wainwright
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依托单位:
Analysis and correction of the host response defect in cystic fibrosis G551D mice.
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批准号:nhmrc : 990175
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项目类别:NHMRC Project Grants
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资助金额:$26.5万
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财政年份:1999
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负责人:Prof Brandon Wainwright
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依托单位:
Inactivation of the patched tumour suppressor gene in the skin of transgenic mice
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批准号:nhmrc : 981824
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项目类别:NHMRC Project Grants
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资助金额:$11.0万
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财政年份:1998
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负责人:Prof Brandon Wainwright
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依托单位:
Structure-function analysis of the patched tumour suppressor gene product
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批准号:nhmrc : 981823
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项目类别:NHMRC Project Grants
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资助金额:$21.49万
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财政年份:1998
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负责人:Prof Brandon Wainwright
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依托单位:
海外基金