Genes controlling the development of lung disease in normal and cystic fibrosis mice.

控制正常和囊性纤维化小鼠肺部疾病发展的基因。

• 批准号: nhmrc : 102523
• 负责人: Prof Brandon Wainwright
• 金额: $ 24.18万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genes-controlling-development-fibrosis-mice/96691
• 关键词: Genes; controlling; development; lung; disease

Patients with cystic fibrosis have a lethal predisposition to bacterial infection which causes irreversible lung disease. It is clear that even when patients carry the same mutation in the defective gene (CFTR), genetic background influences the course of the disease. Very little is known of the nature of these other genes and this proposal will identify those genes which influence the response of the CF lung to pathogens and in doing so may indicate novel therapeutic strategies.

囊性纤维化患者有致命的细菌感染倾向，导致不可逆的肺部疾病。很明显，即使患者在缺陷基因（CFTR）中携带相同的突变，遗传背景也会影响疾病的进程。这些其他基因的性质知之甚少，该提案将确定影响CF肺对病原体的反应的那些基因，并且这样做可能表明新的治疗策略。