Molecular genetics of cystic fibrosis

囊性纤维化的分子遗传学

• 批准号: nhmrc : 252906
• 负责人: Prof Brandon Wainwright
• 金额: $ 39.88万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-genetics-cystic-fibrosis/98201
• 关键词: Molecular; genetics; cystic; fibrosis

Cystic fibrosis is a life-threatening disease of the lungs and digestive system. It is the most common single gene disorder of Caucasian populations and most of the moratility is caused by the presence of chronic lung infections, most notably with the bacterial pathogen, Pseudomonas aeruginosa. Despite the cystic fibrosis gene being discovered over 10 years ago we still have no clear indication as to how defects in the CF gene cause susceptibility to bacterial infections, and result in the inflammation of the lung. Our studies address this issue by examining thechanges of gene expression in response to infection with Pseudomonas aeruginosa and therefore provide us with routes to therapies which are targetted against CF gene mediated inflammation.

囊性纤维化是一种危及生命的肺部和消化系统疾病。它是白种人群体中最常见的单基因疾病，大多数死亡率是由慢性肺部感染引起的，尤其是细菌病原体铜绿假单胞菌感染。尽管囊性纤维化基因在 10 多年前就被发现，但我们仍然没有明确的迹象表明 CF 基因的缺陷如何导致细菌感染的易感性，并导致肺部炎症。我们的研究通过检查铜绿假单胞菌感染引起的基因表达变化来解决这个问题，因此为我们提供了针对 CF 基因介导的炎症的治疗途径。