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Conditional knockout of the murine patched gene for the study of skin differentiation and cancer.

Conditional knockout of the murine patched gene for the study of skin differentiation and cancer.
条件性敲除小鼠补丁基因,用于皮肤分化和癌症的研究。
批准号:
nhmrc : 143073
负责人:
Prof Brandon Wainwright
金额:
$28.24万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2001
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2001-01-01 至 2003-12-31

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中文摘要
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英文摘要
Basal cell carcinoma (BCC) is the most common cancer in Australia. We recently isolated the BCC gene, Patched (PTCH) from analysis of patients with Naevoid Basal Cell Carcinoma Syndrome (NBCCS). Individuals with NBCCS have a wide variety of developmental defects in addition to a cancer predisposition which includes medulloblastoma, rhabdomyosarcoma and ovarian fibroma as well as multiple BCCs. This application proposes the generation of an animal model for skin development and cancer by selectively removing patched gene function from specific cell of the skin. In doing this we will be able to determine the exact role of this gene in skin development, and how mutation causes common skin cancer.
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Identification of genes causing medulloblastoma by transposon mutagenesis.
  • 批准号:
    nhmrc : 1034941
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.47万
  • 财政年份:
    2012
  • 负责人:
    Prof Brandon Wainwright
  • 依托单位:
The intersection between hedgehog and notch signalling in medulloblastoma.
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  • 项目类别:
    NHMRC Project Grants
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    $41.38万
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    2010
  • 负责人:
    Prof Brandon Wainwright
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Molecular genetics of the host response defect in cystic fibrosis
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    nhmrc : 401724
  • 项目类别:
    NHMRC Project Grants
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    $37.65万
  • 财政年份:
    2007
  • 负责人:
    Prof Brandon Wainwright
  • 依托单位:
The role of Patched/Hedgehog signalling in common human cancer.
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    nhmrc : 301198
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $33.06万
  • 财政年份:
    2004
  • 负责人:
    Prof Brandon Wainwright
  • 依托单位:
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  • 项目类别:
    面上项目
  • 资助金额:
    54.0万元
  • 批准年份:
    2011
  • 负责人:
    唐爱发
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大鼠新基因LM23选择性剪接异构体在精子发生中的功能和作用机制研究
在Knockout/knockin (KOI) 小鼠模型中IκBα基因极低表达的整体效应
  • 批准号:
    31070773
  • 项目类别:
    面上项目
  • 资助金额:
    34.0万元
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    2010
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    彭白露
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    30901754
  • 项目类别:
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  • 资助金额:
    20.0万元
  • 批准年份:
    2009
  • 负责人:
    李慧
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