Conditional knockout of the murine patched gene for the study of skin differentiation and cancer.
Conditional knockout of the murine patched gene for the study of skin differentiation and cancer.
批准号:
nhmrc : 143073
负责人:
Prof Brandon Wainwright
金额:
$28.24万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2001
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2001-01-01 至 2003-12-31
中文摘要
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英文摘要
Basal cell carcinoma (BCC) is the most common cancer in Australia. We recently isolated the BCC gene, Patched (PTCH) from analysis of patients with Naevoid Basal Cell Carcinoma Syndrome (NBCCS). Individuals with NBCCS have a wide variety of developmental defects in addition to a cancer predisposition which includes medulloblastoma, rhabdomyosarcoma and ovarian fibroma as well as multiple BCCs. This application proposes the generation of an animal model for skin development and cancer by selectively removing patched gene function from specific cell of the skin. In doing this we will be able to determine the exact role of this gene in skin development, and how mutation causes common skin cancer.
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国内基金
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