The downstream targets of Patched/Hedgehog signalling.

Patched/Hedgehog 信号的下游目标。

• 批准号: nhmrc : 143072
• 负责人: Prof Brandon Wainwright
• 金额: $ 28.21万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/downstream-targets-patchedhedgehog-signalling/94987
• 关键词: downstream; targets; Patched; Hedgehog; signalling.

The patched-hedgehog gene pathway is disturbed in common human cancer, including basal cell carcinoma of the skin, medulloblastoma, rhabdomyosarcoma and ovarian fibroma. This application proposes to look at the genes turned off and on by the patched gene. By identifying these genes and examining their function we will identify the exact genetic disturbance which results in a large proportion of common human cancer. Once we find these genes this opens up the possibilities of designing drugs which specifically block the action of the geneticdefect and thereby treating the tumours.

在常见的人类癌症中，包括皮肤基底细胞癌、成神经管细胞瘤、横纹肌肉瘤和卵巢纤维瘤，patched-hedgehog基因通路受到干扰。这个应用程序提出了看看基因关闭和打开的补丁基因。通过识别这些基因并检查它们的功能，我们将确定导致大部分常见人类癌症的确切遗传紊乱。一旦我们找到这些基因，就有可能设计出专门阻断遗传缺陷作用的药物，从而治疗肿瘤。