The role of Patched/Hedgehog signalling in common human cancer.

Patched/Hedgehog 信号在常见人类癌症中的作用。

• 批准号: nhmrc : 301198
• 负责人: Prof Brandon Wainwright
• 金额: $ 33.06万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-patchedhedgehog-signalling-human-cancer/94855
• 关键词: role; Patched; Hedgehog; signalling; common

Mutations in the patched -hedgehog pathway are responsible for most of the common skin cancer basal cell carcinoma and some of the brain tumour medulloblastoma. Despite this knowledge we still do not know which cell in the skin gives rise to the basal cell carcinoma, and which cell in the brain gives rise to medulloblastoma. This application describes an approach using animal models to answer these questions and therefore further our understanding of how a normal cell becomes a tumour cell. In addition this proposal extends out current studies to examine new gene family members in large tumour collections.

补丁刺猬通路的突变是大多数常见皮肤癌、基底细胞癌和一些脑肿瘤髓母细胞瘤的原因。尽管有这些知识，我们仍然不知道皮肤中的哪种细胞引起基底细胞癌，大脑中的哪种细胞引起髓母细胞瘤。本申请描述了一种使用动物模型来回答这些问题的方法，从而进一步了解正常细胞如何成为肿瘤细胞。此外，该建议扩展了目前的研究，以检查大型肿瘤集合中的新基因家族成员。