Biothermal imaging facility

生物热成像设施

• 批准号: 345420-2007
• 负责人: Kumaradas, Carl
• 金额: $ 4.06万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=326261
• 关键词: Biothermal; imaging; facility

The proposal requests funds to set up a biothermal imaging facility.  The facility will provide the capability of getting images of the surface temperatures from objects from the centimetre scale to the micrometer scale, which span a range of -40 Celsius to 500 Celsius, and at a resolution of 18 micrometres.  It will support three scientists involved in two thermal therapy based research programs.  One program investigates the use of ultrasound transmission imaging to monitor the destruction of tissue during thermal therapy.  The other program is investigating the use of gold nanoparticles conjugated to biomolecules that target specific types of cancer cells, resulting in an uptake of the nanoparticles in tumour regions.  The particles can then be activated using infrared light to heat and destroy only the tumour regions.  The two programs are complimentary in the sense that one is investigating a novel form of targeted thermal therapy, while the other is investigating a novel form of monitoring the progress of thermal therapies, in real-time during treatment.  The proposed facility will greatly benefit both these programs and will provide infrared thermography skills to students to produce highly qualified graduates in Canada.

该提案要求拨款建立一个生物温度成像设施，该设施将提供从厘米尺度到微米尺度的物体表面温度图像的能力，其范围从-40摄氏度到500摄氏度，它的分辨率为18微米。它将支持三位科学家参与两个基于热疗法的研究项目。一个项目研究使用超声波传输成像来监测热疗过程中组织的破坏。另一个项目是研究使用与生物分子结合的金纳米颗粒来靶向特定类型的癌细胞，导致肿瘤区域中纳米颗粒的吸收。然后可以使用红外光激活颗粒以加热并仅破坏肿瘤区域。这两个项目是互补的，一个是研究一种新形式的靶向热疗，而另一个是研究一种新形式的监测热疗的进展，在治疗过程中的实时。拟议的设施将大大有利于这两个项目，并将提供红外热成像技术的学生在加拿大产生高素质的毕业生。