The role of C-reactive protein (CRP) in localising inflammation to misfolded proteins and “stressed” cells: A basis for the development of new anti-inflammatory reagents?

C 反应蛋白 (CRP) 在将炎症定位于错误折叠蛋白和“应激”细胞中的作用：开发新抗炎试剂的基础？

• 批准号: nhmrc : 1067214
• 负责人: Prof Karlheinz Peter
• 金额: $ 48.24万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-c-reactive-inflammatory-reagents/455288
• 关键词: role; reactive; protein; CRP; localising

Many diseases are exacerbated by inflammatory reactions. We describe how a protein circulating in the blood is a major driver of inflammatory reactions and how it is transformed from an inactive state to an active, highly pro-inflammatory state. Our project aims to understand how this transformation occurs at the molecular level, and to develop diagnostic techniques and innovative drugs to treat diseases such as heart attack, Alzheimer’s disease and other inflammatory diseases.

许多疾病因炎症反应而加重。我们描述了血液中循环的蛋白质是如何成为炎症反应的主要驱动力，以及它是如何从不活跃的状态转变为活跃的、高度促炎的状态。我们的项目旨在了解这种转变是如何在分子水平上发生的，并开发诊断技术和创新药物来治疗心脏病发作、阿尔茨海默病和其他炎症性疾病。