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The role of C-reactive protein (CRP) in localising inflammation to misfolded proteins and “stressed” cells: A basis for the development of new anti-inflammatory reagents?

The role of C-reactive protein (CRP) in localising inflammation to misfolded proteins and “stressed” cells: A basis for the development of new anti-inflammatory reagents?
C 反应蛋白 (CRP) 在将炎症定位于错误折叠蛋白和“应激”细胞中的作用:开发新抗炎试剂的基础?
批准号:
nhmrc : 1067214
负责人:
Prof Karlheinz Peter
金额:
$48.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

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中文摘要
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英文摘要
Many diseases are exacerbated by inflammatory reactions. We describe how a protein circulating in the blood is a major driver of inflammatory reactions and how it is transformed from an inactive state to an active, highly pro-inflammatory state. Our project aims to understand how this transformation occurs at the molecular level, and to develop diagnostic techniques and innovative drugs to treat diseases such as heart attack, Alzheimer’s disease and other inflammatory diseases.
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Targeting Activated Platelets: A novel innovative approach for the sensitive detection and therapeutic targeting of various cancers and their metastases
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Targeting Activated Platelets: A novel innovative approach for the sensitive detection and therapeutic targeting of various cancers and their metastases
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Activated platelets as unique targets for early imaging and site-directed therapy of cardiovascular and inflammatory diseases
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    $58.03万
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    2016
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Activated platelets as unique targets for early imaging and site-directed therapy of cardiovascular and inflammatory diseases
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    nhmrc : GNT1108670
  • 项目类别:
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    $84.7万
  • 财政年份:
    2016
  • 负责人:
    Prof Karlheinz Peter
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国内基金
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    30.00万元
  • 批准年份:
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Beclin1复合体在神经酰胺三己糖苷诱导Fabry病自噬障碍中的调控作用及机制研究
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    81100840
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抗单体C反应蛋白抗体在狼疮肾炎中参与补体调理与影响凋亡物质清除的机制研究
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    谭颖
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