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Systems biology to identify molecular targets for vascular disease treatment (SysVasc), with a focus on atherosclerotic plaque instability

Systems biology to identify molecular targets for vascular disease treatment (SysVasc), with a focus on atherosclerotic plaque instability
系统生物学确定血管疾病治疗的分子靶标 (SysVasc),重点关注动脉粥样硬化斑块不稳定性
批准号:
nhmrc : 1102158
负责人:
Prof Karlheinz Peter
金额:
$31.34万
依托单位国家:
澳大利亚
项目类别:
Targeted Calls
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31

项目摘要

项目成果

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中文摘要
翻译
心脏病发作是由血管壁动脉粥样硬化沉积(斑块)破裂引起的,导致血栓形成,最终导致血管闭塞。通过与强大的欧洲合作伙伴的合作,我们将在大型患者队列以及新生成的小鼠模型中使用现代高通量技术来发现致病蛋白,基因及其调节因子。这将有助于识别有风险的个体,并开发新的治疗方法来预防心脏病发作。
英文摘要
Heart attacks are caused by rupture of atherosclerotic deposits (plaques) in vessel walls, which results in clot formation ultimately causing vessel occlusion. In collaboration with strong European collaborators, we will use modern high-throughput technologies in a large patient cohort as well as in a newly generated mouse model to discover the causative proteins, genes and their regulators. This will allow identifying individuals at risk and developing novel therapies to prevent heart attacks.
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Targeting Activated Platelets: A novel innovative approach for the sensitive detection and therapeutic targeting of various cancers and their metastases
  • 批准号:
    nhmrc : GNT1124670
  • 项目类别:
    Project Grants
  • 资助金额:
    $94.84万
  • 财政年份:
    2017
  • 负责人:
    Prof Karlheinz Peter
  • 依托单位:
Targeting Activated Platelets: A novel innovative approach for the sensitive detection and therapeutic targeting of various cancers and their metastases
  • 批准号:
    nhmrc : 1124670
  • 项目类别:
    Project Grants
  • 资助金额:
    $64.74万
  • 财政年份:
    2017
  • 负责人:
    Prof Karlheinz Peter
  • 依托单位:
Activated platelets as unique targets for early imaging and site-directed therapy of cardiovascular and inflammatory diseases
  • 批准号:
    nhmrc : 1108670
  • 项目类别:
    Project Grants
  • 资助金额:
    $58.03万
  • 财政年份:
    2016
  • 负责人:
    Prof Karlheinz Peter
  • 依托单位:
Activated platelets as unique targets for early imaging and site-directed therapy of cardiovascular and inflammatory diseases
  • 批准号:
    nhmrc : GNT1108670
  • 项目类别:
    Project Grants
  • 资助金额:
    $84.7万
  • 财政年份:
    2016
  • 负责人:
    Prof Karlheinz Peter
  • 依托单位:
国内基金
海外基金
组蛋白乙酰化修饰ATG13激活自噬在牵张应力介导骨缝Gli1+干细胞成骨中的机制研究
  • 批准号:
    82370988
  • 项目类别:
    面上项目
  • 资助金额:
    48.00万元
  • 批准年份:
    2023
  • 负责人:
    经典
  • 依托单位:
Journal of Integrative Plant Biology
  • 批准号:
    31024801
  • 项目类别:
    专项基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2010
  • 负责人:
    贺萍
  • 依托单位:
Computational Methods for Analyzing Toponome Data