Systems biology to identify molecular targets for vascular disease treatment (SysVasc), with a focus on atherosclerotic plaque instability

系统生物学确定血管疾病治疗的分子靶标 (SysVasc)，重点关注动脉粥样硬化斑块不稳定性

• 批准号: nhmrc : 1102158
• 负责人: Prof Karlheinz Peter
• 金额: $ 31.34万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/systems-biology-identify-plaque-instability/662589
• 关键词: Systems; biology; identify; molecular; targets

Heart attacks are caused by rupture of atherosclerotic deposits (plaques) in vessel walls, which results in clot formation ultimately causing vessel occlusion. In collaboration with strong European collaborators, we will use modern high-throughput technologies in a large patient cohort as well as in a newly generated mouse model to discover the causative proteins, genes and their regulators. This will allow identifying individuals at risk and developing novel therapies to prevent heart attacks.

心脏病发作是由血管壁中的动脉粥样硬化沉积物（斑块）破裂引起的，这导致凝块形成，最终导致血管闭塞。通过与强大的欧洲合作者合作，我们将在大型患者队列以及新生成的小鼠模型中使用现代高通量技术，以发现致病蛋白质，基因及其调控因子。这将有助于识别有风险的个体，并开发新的治疗方法来预防心脏病发作。