Novel single-chain antibody-targeted nanoparticles for diagnosis of vascular diseases in magnetic resonance imaging

新型单链抗体靶向纳米颗粒用于磁共振成像诊断血管疾病

• 批准号: nhmrc : 472665
• 负责人: Prof Karlheinz Peter
• 金额: $ 30.73万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-single-chain-resonance-imaging/97547
• 关键词: Novel; single; chain; antibody; targeted

The aim of this project is to develop targeted imaging agents that seek out specific markers for various states of cardiovascular disease. These agents would provide a method for detecting the presence and level of atherosclerosis and thrombotic events. The targeted nanoparticles may provide a unique opportunity to detect very early plaques, the vulnerability of existing plaques and difficult to diagnose vessel blockages such as pulmonary embolism.

该项目的目的是开发靶向显像剂，寻找各种心血管疾病状态的特异性标志物。这些试剂将提供用于检测动脉粥样硬化和血栓形成事件的存在和水平的方法。靶向纳米颗粒可以提供一个独特的机会来检测非常早期的斑块，现有斑块的脆弱性和难以诊断的血管阻塞，如肺栓塞。