Nanoparticle and virus assisted targeting of microRNA and DNA for the treatment of atherosclerosis, myocardial infarction and other inflammatory diseases

纳米颗粒和病毒辅助靶向microRNA和DNA治疗动脉粥样硬化、心肌梗死等炎症性疾病

• 批准号: nhmrc : 1069492
• 负责人: Prof Karlheinz Peter
• 金额: $ 44.25万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nanoparticle-virus-assisted-inflammatory-diseases/455397
• 关键词: Nanoparticle; virus; assisted; targeting; microRNA

Inflammation is an underling cause or aggravating factor of many diseases, such as heart attack and atherosclerosis, but there is a lack of effective anti-inflammatory drugs that do not cause side effects. Using advanced biotechnology, we will use viruses and nanoparticles to selectively target gene therapeutics to areas of inflammation, resulting in high efficacy with low side effects. We will test these broadly usable therapeutics in mouse models of heart attack and atherosclerosis.

炎症是许多疾病的潜在原因或加重因素，如心脏病发作和动脉粥样硬化，但缺乏有效的抗炎药，不会造成副作用。利用先进的生物技术，我们将使用病毒和纳米颗粒选择性地针对炎症领域的基因治疗，从而实现高疗效和低副作用。我们将在心脏病发作和动脉粥样硬化的小鼠模型上测试这些广泛使用的疗法。