Therapeutic targeting of CD40L-Mac-1 in inflammatory disease, in particular atherosclerosis
Therapeutic targeting of CD40L-Mac-1 in inflammatory disease, in particular atherosclerosis
批准号:
nhmrc : 586653
负责人:
Prof Karlheinz Peter
金额:
$37.32万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Atherosclerosis is a major burden for human health resulting in myocardial infarction-stroke. We have previously identified a novel interaction between two adhesion molecules, CD40L and Mac-1, which mediates leukocyte adhesion to endothelial cells being a major determinant of atherosclerotic plaque development. We are now developing blocking peptides and recombinant antibodies thereby exploring various anti-inflammatory- anti-atherosclerotic strategies, targeting both Mac-1 and CD40L.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Targeting Activated Platelets: A novel innovative approach for the sensitive detection and therapeutic targeting of various cancers and their metastases
-
批准号:nhmrc : GNT1124670
-
项目类别:Project Grants
-
资助金额:$94.84万
-
财政年份:2017
-
负责人:Prof Karlheinz Peter
-
依托单位:
Targeting Activated Platelets: A novel innovative approach for the sensitive detection and therapeutic targeting of various cancers and their metastases
-
批准号:nhmrc : 1124670
-
项目类别:Project Grants
-
资助金额:$64.74万
-
财政年份:2017
-
负责人:Prof Karlheinz Peter
-
依托单位:
Activated platelets as unique targets for early imaging and site-directed therapy of cardiovascular and inflammatory diseases
-
批准号:nhmrc : 1108670
-
项目类别:Project Grants
-
资助金额:$58.03万
-
财政年份:2016
-
负责人:Prof Karlheinz Peter
-
依托单位:
Activated platelets as unique targets for early imaging and site-directed therapy of cardiovascular and inflammatory diseases
-
批准号:nhmrc : GNT1108670
-
项目类别:Project Grants
-
资助金额:$84.7万
-
财政年份:2016
-
负责人:Prof Karlheinz Peter
-
依托单位:
Defining targets and establishing methods for prevention, diagnosis and therapy of inflammation, atherosclerosis and thrombosis
-
批准号:nhmrc : 1079492
-
项目类别:Research Fellowships
-
资助金额:$56.51万
-
财政年份:2015
-
负责人:Prof Karlheinz Peter
-
依托单位:
Defining targets and establishing methods for prevention, diagnosis and therapy of inflammation, atherosclerosis and thrombosis
-
批准号:nhmrc : GNT1079492
-
项目类别:Research Fellowships
-
资助金额:$81.5万
-
财政年份:2015
-
负责人:Prof Karlheinz Peter
-
依托单位:
Systems biology to identify molecular targets for vascular disease treatment (SysVasc), with a focus on atherosclerotic plaque instability
-
批准号:nhmrc : 1102158
-
项目类别:Targeted Calls
-
资助金额:$31.34万
-
财政年份:2015
-
负责人:Prof Karlheinz Peter
-
依托单位:
Systems biology to identify molecular targets for vascular disease treatment (SysVasc), with a focus on atherosclerotic plaque instability
-
批准号:nhmrc : GNT1102158
-
项目类别:International Collaborations
-
资助金额:$45.07万
-
财政年份:2015
-
负责人:Prof Karlheinz Peter
-
依托单位:
Nanoparticle and virus assisted targeting of microRNA and DNA for the treatment of atherosclerosis, myocardial infarction and other inflammatory diseases
-
批准号:nhmrc : 1069492
-
项目类别:Project Grants
-
资助金额:$44.25万
-
财政年份:2014
-
负责人:Prof Karlheinz Peter
-
依托单位:
Defining "therapeutic" cells as well as establishing cell targeting and tracking technology for the treatment of myocardial infarction and atherosclerosis.
-
批准号:nhmrc : 1070860
-
项目类别:Project Grants
-
资助金额:$44.32万
-
财政年份:2014
-
负责人:Prof Karlheinz Peter
-
依托单位:
The role of C-reactive protein (CRP) in localising inflammation to misfolded proteins and “stressed” cells: A basis for the development of new anti-inflammatory reagents?
-
批准号:nhmrc : 1067214
-
项目类别:Project Grants
-
资助金额:$48.24万
-
财政年份:2014
-
负责人:Prof Karlheinz Peter
-
依托单位:
Developing functionalised microbubbles for molecular ultrasound imaging and targeted delivery of drugs and microRNA therapeutics
-
批准号:nhmrc : 1050018
-
项目类别:Project Grants
-
资助金额:$45.16万
-
财政年份:2013
-
负责人:Prof Karlheinz Peter
-
依托单位:
Defining targets and generating tools/therapeutic agents for prevention, diagnosis and therapy of atherothrombosis
-
批准号:FT0992210
-
项目类别:ARC Future Fellowships
-
资助金额:$56.26万
-
财政年份:2010
-
负责人:Prof Karlheinz Peter
-
依托单位:
Research Fellowship
-
批准号:nhmrc : 586652
-
项目类别:NHMRC Research Fellowships
-
资助金额:$10.08万
-
财政年份:2010
-
负责人:Prof Karlheinz Peter
-
依托单位:
Platelet-Activating and Proinflammatory Effects of Proteins Secreted by Staphylococcus aureus
-
批准号:nhmrc : 526626
-
项目类别:NHMRC Project Grants
-
资助金额:$34.41万
-
财政年份:2009
-
负责人:Prof Karlheinz Peter
-
依托单位:
Novel single-chain antibody-targeted nanoparticles for diagnosis of vascular diseases in magnetic resonance imaging
-
批准号:nhmrc : 472665
-
项目类别:NHMRC Development Grants
-
资助金额:$30.73万
-
财政年份:2008
-
负责人:Prof Karlheinz Peter
-
依托单位:
Novel selective anti-platelet and clot-specific anticoagulant strategies targeting conformational states of GPIIb/IIIa
-
批准号:nhmrc : 367645
-
项目类别:NHMRC Project Grants
-
资助金额:$33.11万
-
财政年份:2006
-
负责人:Prof Karlheinz Peter
-
依托单位:
国内基金
海外基金
登录
查看更多内容
靶向PARylation介导的DNA损伤修复途径在恶性肿瘤治疗中的作用与分子机制研究
-
批准号:82373145
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:历鹏
-
依托单位:
诱导性多能干细胞rDNA区基因打靶在线粒体视神经病中的治疗研究
-
批准号:81970829
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:李卓
-
依托单位:
Pre-targeting/Click反应介导的自体循环干细胞在心脏缺血损伤修复中的应用及机制研究
-
批准号:81873493
-
项目类别:面上项目
-
资助金额:57.0万元
-
批准年份:2018
-
负责人:沈德良
-
依托单位:
以IGF2/IGF1R与SYT/SSX1为靶点治疗滑膜肉瘤的实验研究
-
批准号:81102033
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2011
-
负责人:李大森
-
依托单位:
基于ZFN/phiC31系统的新型基因打靶技术的建立(果蝇)
-
批准号:31171278
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2011
-
负责人:高冠军
-
依托单位:
APO-miR(multi-targeting apoptosis-regulatory miRNA)在前列腺癌中的表达和作用
-
批准号:81101529
-
项目类别:青年科学基金项目
-
资助金额:22.0万元
-
批准年份:2011
-
负责人:陈雪芹
-
依托单位: