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Therapeutic targeting of CD40L-Mac-1 in inflammatory disease, in particular atherosclerosis

Therapeutic targeting of CD40L-Mac-1 in inflammatory disease, in particular atherosclerosis
CD40L-Mac-1 在炎症性疾病(特别是动脉粥样硬化)中的治疗靶向
批准号:
nhmrc : 586653
负责人:
Prof Karlheinz Peter
金额:
$37.32万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
Atherosclerosis is a major burden for human health resulting in myocardial infarction-stroke. We have previously identified a novel interaction between two adhesion molecules, CD40L and Mac-1, which mediates leukocyte adhesion to endothelial cells being a major determinant of atherosclerotic plaque development. We are now developing blocking peptides and recombinant antibodies thereby exploring various anti-inflammatory- anti-atherosclerotic strategies, targeting both Mac-1 and CD40L.
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