The role of meninges in midbrain dopamine development

脑膜在中脑多巴胺发育中的作用

• 批准号: nhmrc : 1079762
• 负责人: A/Pr Clare Parish
• 金额: $ 25.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-meninges-midbrain-dopamine-development/518700
• 关键词: role; meninges; midbrain; dopamine; development

Dopamine neurons are important for the control of movement, emotion and cognitive function, and are affected in a number of disorders such as Parkinson’s disease. Instrumental in improving our knowledge of disease etiology and the development of new therapies will be a greater understanding of how these cells are initially born during development. This project examines the role of the brain’s meninges in dopamine development and repair and will identify proteins and signaling pathways involved.

多巴胺神经元对于运动、情绪和认知功能的控制很重要，并且在帕金森病等许多疾病中受到影响。更好地了解这些细胞在发育过程中最初是如何产生的，有助于提高我们对疾病病因学的了解和新疗法的开发。该项目研究大脑脑膜在多巴胺发育和修复中的作用，并将识别相关的蛋白质和信号通路。