Biomaterials for the direct reprograming of reactive astrocytes into functional neurons

用于将反应性星形胶质细胞直接重编程为功能性神经元的生物材料

• 批准号: nhmrc : 1144996
• 负责人: A/Pr Clare Parish
• 金额: $ 42.63万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biomaterials-direct-reprograming-functional-neurons/1320334
• 关键词: Biomaterials; direct; reprograming; reactive; astrocytes

We will employ peptide inspired hydrogel nanoscaffolds that can be injected into a brain lesion as a single injection to provide chemical and physical support for the surrounding cells. We will utilize various modifications to these materials to reprogram inflammatory cells into neurons, whilst also promoting the survival, maintenance and growth of existing neurons to encourage repair.

我们将采用肽启发的水凝胶纳米支架，可以作为单次注射注入脑损伤，为周围细胞提供化学和物理支持。我们将利用对这些材料的各种修饰将炎症细胞重新编程为神经元，同时还促进现有神经元的存活，维持和生长以促进修复。