Testing the Prion Hypothesis in Parkinson’s Disease using a Novel In Vivo Model of ?-synuclein Transmission
Testing the Prion Hypothesis in Parkinson’s Disease using a Novel In Vivo Model of ?-synuclein Transmission
批准号:
nhmrc : 1145348
负责人:
A/Pr Clare Parish
金额:
$42.09万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Parkinson’s Disease (PD) is a debilitating neurological disease with no cure. Recently it has been discovered that the disease can spread through the brain. We have developed the worlds first animal model to study exactly how the disease propagates inside of neurons during this spread. We will use the model to answer key questions about this critical stage of disease spread, knowledge that is essential for the development of successful therapies to prevent disease progression.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Advancing stem cell therapy for brain repair
-
批准号:nhmrc : GNT1154744
-
项目类别:Research Fellowships
-
资助金额:$64.92万
-
财政年份:2019
-
负责人:A/Pr Clare Parish
-
依托单位:
Biomaterials for the direct reprograming of reactive astrocytes into functional neurons
-
批准号:nhmrc : 1144996
-
项目类别:Project Grants
-
资助金额:$42.63万
-
财政年份:2018
-
负责人:A/Pr Clare Parish
-
依托单位:
Biomaterials for the direct reprograming of reactive astrocytes into functional neurons
-
批准号:nhmrc : GNT1144996
-
项目类别:Project Grants
-
资助金额:$63.05万
-
财政年份:2018
-
负责人:A/Pr Clare Parish
-
依托单位:
Using stem cells and bioengineered scaffolds to promote regeneration following necrotic brain injury
-
批准号:nhmrc : GNT1122974
-
项目类别:Project Grants
-
资助金额:$71.09万
-
财政年份:2017
-
负责人:A/Pr Clare Parish
-
依托单位:
Using stem cells and bioengineered scaffolds to promote regeneration following necrotic brain injury
-
批准号:nhmrc : 1122974
-
项目类别:Project Grants
-
资助金额:$48.54万
-
财政年份:2017
-
负责人:A/Pr Clare Parish
-
依托单位:
Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease
-
批准号:nhmrc : GNT1102704
-
项目类别:Project Grants
-
资助金额:$98.77万
-
财政年份:2016
-
负责人:A/Pr Clare Parish
-
依托单位:
Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease
-
批准号:nhmrc : 1102704
-
项目类别:Project Grants
-
资助金额:$68.06万
-
财政年份:2016
-
负责人:A/Pr Clare Parish
-
依托单位:
The role of meninges in midbrain dopamine development
-
批准号:nhmrc : 1079762
-
项目类别:Project Grants
-
资助金额:$25.23万
-
财政年份:2015
-
负责人:A/Pr Clare Parish
-
依托单位:
The role of meninges in midbrain dopamine development
-
批准号:nhmrc : GNT1079762
-
项目类别:Project Grants
-
资助金额:$24.43万
-
财政年份:2015
-
负责人:A/Pr Clare Parish
-
依托单位:
Selective isolation and in vivo properties of dopamine neurons generated from embryonic stem cells.
-
批准号:nhmrc : 1042585
-
项目类别:Project Grants
-
资助金额:$33.7万
-
财政年份:2013
-
负责人:A/Pr Clare Parish
-
依托单位:
Knowledge, Identification and Exploitation of dopaminergic axon guidance cues will improve cell replacement therapy for ParkinsonÍs disease.
-
批准号:nhmrc : 1022637
-
项目类别:Project Grants
-
资助金额:$32.13万
-
财政年份:2012
-
负责人:A/Pr Clare Parish
-
依托单位:
Restoration of the nigrostriatal pathway in the Parkinsonian brain
-
批准号:nhmrc : 628542
-
项目类别:NHMRC Project Grants
-
资助金额:$19.97万
-
财政年份:2010
-
负责人:A/Pr Clare Parish
-
依托单位:
Wnt signaling in dopaminergic neuronal connectivity
-
批准号:nhmrc : 566582
-
项目类别:Career Development Fellowships
-
资助金额:$25.84万
-
财政年份:2009
-
负责人:A/Pr Clare Parish
-
依托单位:
Wnt signaling in dopaminergic neuronal connectivity
-
批准号:nhmrc : 566740
-
项目类别:NHMRC Project Grants
-
资助金额:$37.66万
-
财政年份:2009
-
负责人:A/Pr Clare Parish
-
依托单位:
Development of stem cell therapies for Parkinson's disease.
-
批准号:nhmrc : 237025
-
项目类别:Early Career Fellowships
-
资助金额:$21.8万
-
财政年份:2003
-
负责人:A/Pr Clare Parish
-
依托单位:
国内基金
海外基金
登录
查看更多内容
Prion疾病中PINK1-Parkin介导神经元线粒体自噬受损及PINK1失稳机制的研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:54万元
-
批准年份:2022
-
负责人:杨利峰
-
依托单位:
免疫调节因子Progranulin在Prion致神经退变中的作用和分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:朱采红
-
依托单位:
补铁药物抑制PrPC表达在Prion病中的作用及机制研究
-
批准号:82101502
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:李蓓
-
依托单位:
Retromer-VPS35在Prion疾病引起神经元线粒体动力学失衡中的调控机制
-
批准号:31972641
-
项目类别:面上项目
-
资助金额:59.0万元
-
批准年份:2019
-
负责人:杨利峰
-
依托单位:
基于prion构象转变的分子机理设计和发现调控朊蛋白错误折叠和聚集的小分子和肽类抑制剂
-
批准号:21675070
-
项目类别:面上项目
-
资助金额:65.0万元
-
批准年份:2016
-
负责人:刘焕香
-
依托单位:
酵母prion蛋白Ure2的寡聚及构象变化的单分子水平研究
-
批准号:21673278
-
项目类别:面上项目
-
资助金额:65.0万元
-
批准年份:2016
-
负责人:吴思
-
依托单位:
朊病毒Prion淀粉样纤维的三维结构固体核磁共振研究
-
批准号:31600613
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2016
-
负责人:赵伟静
-
依托单位:
APP/PS1双转基因阿尔茨海默氏病鼠的神经发生与Prion蛋白的关系
-
批准号:81300923
-
项目类别:青年科学基金项目
-
资助金额:21.5万元
-
批准年份:2013
-
负责人:俞英欣
-
依托单位:
pro-prion 对胰腺癌恶性转化的机理研究
-
批准号:81172376
-
项目类别:面上项目
-
资助金额:57.0万元
-
批准年份:2011
-
负责人:李朝阳
-
依托单位:
Cystatin B缺失与Prion疾病自噬作用机制的研究
-
批准号:31172293
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2011
-
负责人:赵德明
-
依托单位: