Testing the Prion Hypothesis in Parkinson’s Disease using a Novel In Vivo Model of ?-synuclein Transmission

使用新型体内 β-突触核蛋白传播模型测试帕金森病中的朊病毒假说

• 批准号: nhmrc : 1145348
• 负责人: A/Pr Clare Parish
• 金额: $ 42.09万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/testing-prion-hypothesis-synuclein-transmission/1320430
• 关键词: Testing; Prion; Hypothesis; Parkinson; Disease

Parkinson’s Disease (PD) is a debilitating neurological disease with no cure. Recently it has been discovered that the disease can spread through the brain. We have developed the worlds first animal model to study exactly how the disease propagates inside of neurons during this spread. We will use the model to answer key questions about this critical stage of disease spread, knowledge that is essential for the development of successful therapies to prevent disease progression.

帕金森病（PD）是一种无法治愈的衰弱性神经系统疾病。最近发现这种疾病可以通过大脑传播。我们开发了世界上第一个动物模型来研究疾病在这种传播过程中如何在神经元内传播。我们将使用该模型来回答有关疾病传播这一关键阶段的关键问题，这些知识对于开发成功的治疗方法以预防疾病进展至关重要。