Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease

帕金森病中人类多能干细胞来源的神经移植的分化和整合标准化方案

• 批准号: nhmrc : GNT1102704
• 负责人: A/Pr Clare Parish
• 金额: $ 98.77万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/standardising-protocols-differentiation-parkinsons-disease/1346234
• 关键词: Standardising; protocols; differentiation; integration; human

Clinical trials have shown that transplanting dopamine neurons (specific nerve cells) into the brain of Parkinson’s disease patients can improve symptoms. Trials use fetal tissue for implantation, which is unsustainable and highly variable. This proposal will examine stem cells as an alternative. We will establish a reliable protocol to instruct human stem cells to become dopamine neurons, develop methods to select these cells and, examine the integration of these transplanted cells in the brain

临床试验表明，将多巴胺神经元（特定神经细胞）移植到帕金森病患者的大脑中可以改善症状。试验使用胎儿组织进行植入，这是不可持续的且变化很大。该提案将检查干细胞作为替代方案。我们将建立一个可靠的方案来指导人类干细胞成为多巴胺神经元，开发选择这些细胞的方法，并检查这些移植细胞在大脑中的整合