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Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease

Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease
帕金森病中人类多能干细胞来源的神经移植的分化和整合标准化方案
批准号:
nhmrc : GNT1102704
负责人:
A/Pr Clare Parish
金额:
$98.77万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --

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中文摘要
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英文摘要
Clinical trials have shown that transplanting dopamine neurons (specific nerve cells) into the brain of Parkinson’s disease patients can improve symptoms. Trials use fetal tissue for implantation, which is unsustainable and highly variable. This proposal will examine stem cells as an alternative. We will establish a reliable protocol to instruct human stem cells to become dopamine neurons, develop methods to select these cells and, examine the integration of these transplanted cells in the brain
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Advancing stem cell therapy for brain repair
  • 批准号:
    nhmrc : GNT1154744
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.92万
  • 财政年份:
    2019
  • 负责人:
    A/Pr Clare Parish
  • 依托单位:
Biomaterials for the direct reprograming of reactive astrocytes into functional neurons
  • 批准号:
    nhmrc : 1144996
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.63万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Clare Parish
  • 依托单位:
Biomaterials for the direct reprograming of reactive astrocytes into functional neurons
  • 批准号:
    nhmrc : GNT1144996
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.05万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Clare Parish
  • 依托单位:
Testing the Prion Hypothesis in Parkinson’s Disease using a Novel In Vivo Model of ?-synuclein Transmission
  • 批准号:
    nhmrc : 1145348
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.09万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Clare Parish
  • 依托单位:
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