Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease
Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease
批准号:
nhmrc : GNT1102704
负责人:
A/Pr Clare Parish
金额:
$98.77万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
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英文摘要
Clinical trials have shown that transplanting dopamine neurons (specific nerve cells) into the brain of Parkinson’s disease patients can improve symptoms. Trials use fetal tissue for implantation, which is unsustainable and highly variable. This proposal will examine stem cells as an alternative. We will establish a reliable protocol to instruct human stem cells to become dopamine neurons, develop methods to select these cells and, examine the integration of these transplanted cells in the brain
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负责人:A/Pr Clare Parish
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依托单位:
Standardising protocols for the differentiation and integration of human pluripotent stem cell-derived neural transplants in Parkinson's disease
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依托单位:
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Wnt signaling in dopaminergic neuronal connectivity
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依托单位:
Wnt signaling in dopaminergic neuronal connectivity
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负责人:A/Pr Clare Parish
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依托单位:
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依托单位:
海外基金