Novel asymmetric synthesis of helically and planar chiral molecules

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During the last few decades the science of asymmetric catalysis has experienced significant advances. However, as Nature continues to supply organic chemists with new and fascinating chemical structures, it also presents us with new challenges. These new challenges demand technologies that are ever more general, practical, environmentally friendly and powerful. Consequently, asymmetric synthesis continues to evolve and existing synthetic methods are often replaced as more effective methods are developed. The specific goal of the research program is to develop new methods for the stereoselective synthesis of molecules possessing helical and planar chirality. The molecules that possess this unique chemical property are of considerable importance. These molecules are found across many scientific disciplines and in many industrial applications (pharmaceuticals, agrochemicals, biology, biochemistry, food sciences, etc.). Considering today's demand for enantiomerically pure compounds, our proposed research focuses on developing new catalytic strategies to construct these molecules.