A single nucleotide resolution map of a cancer associated neochromosome

癌症相关新染色体的单核苷酸分辨率图

• 批准号: nhmrc : 1004022
• 负责人: Prof Anthony Papenfuss
• 金额: $ 37.83万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/single-nucleotide-resolution-associated-neochromosome/108991
• 关键词: single; nucleotide; resolution; map; cancer

Neochromosomes (NCs) are large chromosomes which are not usually found in a normal cell. Well differentiated liposarcoma (WDLPS) is a tumour which is almost universally associated with the presence of NCs. We are using the approach of purifying the NC from a series of WDLPS cell lines, and using new techniques to derive the DNA sequence of the neochromosome. We will use this information to identify the genetic factors on the NC which are involved in the initiation or progression of WDLPS.

新染色体（NCs）是在正常细胞中不常见的大染色体。高分化脂肪肉瘤（WDLPS）是一种几乎普遍与nc存在相关的肿瘤。我们正在采用从一系列WDLPS细胞系中纯化NC的方法，并使用新技术获得新染色体的DNA序列。我们将利用这些信息来确定NC上参与WDLPS发生或进展的遗传因素。