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DNA nanotechnology for controlled antigen presentation to T cells

DNA nanotechnology for controlled antigen presentation to T cells
DNA 纳米技术可控制抗原呈递至 T 细胞
批准号:
DP170102727
负责人:
Prof Katharina Gaus
金额:
$33.97万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-03-01

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中文摘要
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英文摘要
The project aims to present individual antigens to T cells and to image T cell receptor signalling with single molecule microscopy. Combining DNA origami nanotechnology with single molecule imaging should reveal the sensitivity of T cell signalling. A DNA force sensor will determine whether mechanical forces contribute to antigen discrimination. The project will use the nanotechnology strategy to identify antigen-specific T cells in tissue. The project is expected to advance understanding of T cell biology, and contribute to DNA nanotechnology and super-resolution microscopy whilst providing fundamental insights into antigen recognition by T cells and ultimately derive clinically relevant practical applications.
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T cell receptor (TCR) singalling efficiency
  • 批准号:
    nhmrc : GNT1155162
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.92万
  • 财政年份:
    2019
  • 负责人:
    Prof Katharina Gaus
  • 依托单位:
Confocal and single molecule microscopes for systems microscopy
  • 批准号:
    LE180100157
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $40.01万
  • 财政年份:
    2018
  • 负责人:
    Prof Katharina Gaus
  • 依托单位:
Statistical analyses for spatial organisation in T cell signalling networks
  • 批准号:
    DP170103599
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $27.9万
  • 财政年份:
    2017
  • 负责人:
    Prof Katharina Gaus
  • 依托单位:
Modulating T cell responses with novel Lck activating compounds
  • 批准号:
    LP160100979
  • 项目类别:
    Linkage Projects
  • 资助金额:
    $23.3万
  • 财政年份:
    2016
  • 负责人:
    Prof Katharina Gaus
  • 依托单位:
海外基金