DNA nanotechnology for controlled antigen presentation to T cells
DNA nanotechnology for controlled antigen presentation to T cells
批准号:
DP170102727
负责人:
Prof Katharina Gaus
金额:
$33.97万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-03-01
中文摘要
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英文摘要
The project aims to present individual antigens to T cells and to image T cell receptor signalling with single molecule microscopy. Combining DNA origami nanotechnology with single molecule imaging should reveal the sensitivity of T cell signalling. A DNA force sensor will determine whether mechanical forces contribute to antigen discrimination. The project will use the nanotechnology strategy to identify antigen-specific T cells in tissue. The project is expected to advance understanding of T cell biology, and contribute to DNA nanotechnology and super-resolution microscopy whilst providing fundamental insights into antigen recognition by T cells and ultimately derive clinically relevant practical applications.
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T cell receptor (TCR) singalling efficiency
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批准号:nhmrc : GNT1155162
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项目类别:Research Fellowships
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资助金额:$64.92万
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财政年份:2019
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负责人:Prof Katharina Gaus
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依托单位:
Confocal and single molecule microscopes for systems microscopy
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批准号:LE180100157
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$40.01万
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财政年份:2018
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负责人:Prof Katharina Gaus
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依托单位:
Statistical analyses for spatial organisation in T cell signalling networks
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批准号:DP170103599
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项目类别:Discovery Projects
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资助金额:$27.9万
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财政年份:2017
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负责人:Prof Katharina Gaus
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依托单位:
Modulating T cell responses with novel Lck activating compounds
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批准号:LP160100979
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项目类别:Linkage Projects
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资助金额:$23.3万
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财政年份:2016
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负责人:Prof Katharina Gaus
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依托单位:
Single molecule imaging laboratory
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批准号:LE150100163
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$37.34万
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财政年份:2015
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负责人:Prof Katharina Gaus
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依托单位:
Connecting the dots: Image analysis for single molecule localisation microscopy
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批准号:LP140100967
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项目类别:Linkage Projects
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资助金额:$27.23万
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财政年份:2015
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负责人:Prof Katharina Gaus
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依托单位:
Spatial organization of T cell signalling
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批准号:nhmrc : GNT1059278
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项目类别:Research Fellowships
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资助金额:$60.14万
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财政年份:2014
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负责人:Prof Katharina Gaus
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依托单位:
Spatial organization of T cell signalling
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批准号:nhmrc : 1059278
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项目类别:Research Fellowships
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资助金额:$42.08万
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财政年份:2014
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负责人:Prof Katharina Gaus
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依托单位:
Nano-scale organisation of cellular adhesions
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批准号:DP130100269
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项目类别:Discovery Projects
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资助金额:$33.04万
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财政年份:2013
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负责人:Prof Katharina Gaus
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依托单位:
Molecular interactions in cell membranes
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批准号:LP110100390
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项目类别:Linkage Projects
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资助金额:$30.27万
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财政年份:2012
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负责人:Prof Katharina Gaus
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依托单位:
Life at the nanometre scale: imaging immunological synapses with a novel super-resolution fluorescence microscope
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批准号:LP100200021
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项目类别:Linkage Projects
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资助金额:$30.06万
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财政年份:2011
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负责人:Prof Katharina Gaus
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依托单位:
Molecular microscopy: protein and membrane dynamics in resting and activated T cells
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批准号:DP1095468
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项目类别:Discovery Projects
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资助金额:$22.99万
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财政年份:2010
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负责人:Prof Katharina Gaus
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依托单位:
Super-resolution fluorescence microscopy
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批准号:LE100100089
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$46.68万
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财政年份:2010
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负责人:Prof Katharina Gaus
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 568716
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项目类别:NHMRC Research Fellowships
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资助金额:$38.72万
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财政年份:2009
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负责人:Prof Katharina Gaus
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依托单位:
High-resolution imaging of live cells and tissue
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批准号:LE0882855
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$60.01万
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财政年份:2008
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负责人:Prof Katharina Gaus
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依托单位:
Molecular mechanisms in cholesterol export.
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批准号:nhmrc : 455301
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项目类别:NHMRC Project Grants
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资助金额:$34.41万
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财政年份:2007
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负责人:Prof Katharina Gaus
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依托单位:
Lipid raft and cyotoskeleton organization: How membrane domains give cells direction
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批准号:DP0556554
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项目类别:Discovery Projects
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资助金额:$17.56万
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财政年份:2005
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负责人:Prof Katharina Gaus
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依托单位:
Lipid raft organisation in mammalian cells
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批准号:nhmrc : 350986
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项目类别:Career Development Fellowships
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资助金额:$23.95万
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财政年份:2005
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负责人:Prof Katharina Gaus
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依托单位:
Cholesterol-dependent control of plasma membrane lipid rafts
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批准号:DP0212068
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项目类别:Discovery Projects
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资助金额:$16.13万
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财政年份:2002
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负责人:Prof Katharina Gaus
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依托单位:
海外基金