Molecular microscopy: protein and membrane dynamics in resting and activated T cells
Molecular microscopy: protein and membrane dynamics in resting and activated T cells
批准号:
DP1095468
负责人:
Prof Katharina Gaus
金额:
$22.99万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2013-03-31
中文摘要
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英文摘要
The aim of this research, to understand the molecular organization and dynamics of the plasma membrane that underlie the signal transduction events, is at the very heart of understanding cell communication. T cell recognition and activation initiates an adaptive immune response to invading pathogens and structurally altered proteins that can be found in cancers. By providing functional insights into the molecular mechanism of T cell activation, we will not only provide fundamental knowledge of receptor signalling but also specific details of T cell receptort triggering that may lead to the development of new therapeutic strategies to control T cell activation.
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Molecular mechanisms in cholesterol export.
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Lipid raft organisation in mammalian cells
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Cholesterol-dependent control of plasma membrane lipid rafts
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依托单位:
国内基金
海外基金
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