Lipid raft and cyotoskeleton organization: How membrane domains give cells direction
Lipid raft and cyotoskeleton organization: How membrane domains give cells direction
批准号:
DP0556554
负责人:
Prof Katharina Gaus
金额:
$17.56万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2005
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2005-01-01 至 2010-06-30
中文摘要
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英文摘要
For a large number of cells in our body it is imperative that they are able to orientate themselves relative to their environment, sense direction and translate incoming signals. To do so it is hypothesised that lipids on the cell surface are redistributed to form specialized domains. An asymmetric distribution of membrane domains can provide cells with a front and rear end and can further concentrate and co-ordinate signalling molecules to a specific site. The project will determine the role of lipid domain in stabilizing cell shape and their remodelling during cell migration, the digestion of foreign particles and the formation of cell-cell contacts.
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