Life at the nanometre scale: imaging immunological synapses with a novel super-resolution fluorescence microscope
Life at the nanometre scale: imaging immunological synapses with a novel super-resolution fluorescence microscope
批准号:
LP100200021
负责人:
Prof Katharina Gaus
金额:
$30.06万
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-03-18 至 2014-12-31
中文摘要
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英文摘要
This project aims to image individual proteins in activated white blood cells in order to understand how lymphocytes participate in an immune response. The problem is that current imaging modalities either lack resolution or are unsuitable for live cell and three-dimensional (3D) imaging. With the project’s industry partner, Carl Zeiss MicroImaging, the project will build and apply a novel microscope that is capable of visualising single proteins in 3D and live cells. This technology will provide insights into signalling and lymphocyte function on a true molecular scale.
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T cell receptor (TCR) singalling efficiency
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批准号:nhmrc : GNT1155162
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项目类别:Research Fellowships
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资助金额:$64.92万
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财政年份:2019
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负责人:Prof Katharina Gaus
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依托单位:
Confocal and single molecule microscopes for systems microscopy
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批准号:LE180100157
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$40.01万
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财政年份:2018
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负责人:Prof Katharina Gaus
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依托单位:
DNA nanotechnology for controlled antigen presentation to T cells
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批准号:DP170102727
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项目类别:Discovery Projects
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资助金额:$33.97万
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财政年份:2017
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负责人:Prof Katharina Gaus
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依托单位:
Statistical analyses for spatial organisation in T cell signalling networks
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批准号:DP170103599
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项目类别:Discovery Projects
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资助金额:$27.9万
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财政年份:2017
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负责人:Prof Katharina Gaus
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依托单位:
Modulating T cell responses with novel Lck activating compounds
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批准号:LP160100979
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项目类别:Linkage Projects
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资助金额:$23.3万
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财政年份:2016
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负责人:Prof Katharina Gaus
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依托单位:
Single molecule imaging laboratory
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批准号:LE150100163
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$37.34万
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财政年份:2015
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负责人:Prof Katharina Gaus
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依托单位:
Connecting the dots: Image analysis for single molecule localisation microscopy
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批准号:LP140100967
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项目类别:Linkage Projects
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资助金额:$27.23万
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财政年份:2015
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负责人:Prof Katharina Gaus
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依托单位:
Spatial organization of T cell signalling
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批准号:nhmrc : GNT1059278
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项目类别:Research Fellowships
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资助金额:$60.14万
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财政年份:2014
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负责人:Prof Katharina Gaus
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依托单位:
Spatial organization of T cell signalling
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批准号:nhmrc : 1059278
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项目类别:Research Fellowships
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资助金额:$42.08万
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财政年份:2014
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负责人:Prof Katharina Gaus
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依托单位:
Nano-scale organisation of cellular adhesions
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批准号:DP130100269
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项目类别:Discovery Projects
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资助金额:$33.04万
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财政年份:2013
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负责人:Prof Katharina Gaus
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依托单位:
Molecular interactions in cell membranes
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批准号:LP110100390
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项目类别:Linkage Projects
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资助金额:$30.27万
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财政年份:2012
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负责人:Prof Katharina Gaus
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依托单位:
Molecular microscopy: protein and membrane dynamics in resting and activated T cells
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批准号:DP1095468
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项目类别:Discovery Projects
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资助金额:$22.99万
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财政年份:2010
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负责人:Prof Katharina Gaus
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依托单位:
Super-resolution fluorescence microscopy
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批准号:LE100100089
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$46.68万
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财政年份:2010
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负责人:Prof Katharina Gaus
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 568716
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项目类别:NHMRC Research Fellowships
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资助金额:$38.72万
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财政年份:2009
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负责人:Prof Katharina Gaus
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依托单位:
High-resolution imaging of live cells and tissue
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批准号:LE0882855
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$60.01万
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财政年份:2008
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负责人:Prof Katharina Gaus
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依托单位:
Molecular mechanisms in cholesterol export.
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批准号:nhmrc : 455301
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项目类别:NHMRC Project Grants
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资助金额:$34.41万
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财政年份:2007
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负责人:Prof Katharina Gaus
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依托单位:
Lipid raft and cyotoskeleton organization: How membrane domains give cells direction
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批准号:DP0556554
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项目类别:Discovery Projects
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资助金额:$17.56万
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财政年份:2005
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负责人:Prof Katharina Gaus
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依托单位:
Lipid raft organisation in mammalian cells
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批准号:nhmrc : 350986
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项目类别:Career Development Fellowships
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资助金额:$23.95万
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财政年份:2005
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负责人:Prof Katharina Gaus
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依托单位:
Cholesterol-dependent control of plasma membrane lipid rafts
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批准号:DP0212068
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项目类别:Discovery Projects
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资助金额:$16.13万
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财政年份:2002
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负责人:Prof Katharina Gaus
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依托单位:
海外基金