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INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE

INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
炎症小体和白细胞介素 18 信号传导:肾脏疾病的新型生物标志物和治疗靶点
批准号:
nhmrc : GNT1143674
负责人:
A/Pr Ashley Mansell
金额:
$100.33万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
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英文摘要
Chronic kidney disease (CKD) is a major health problem. There is no cure for CKD and current therapies merely slow its progression. Thus for many patients, dialysis or kidney transplant is an inevitable outcome. We have evidence that a protein called interleukin-18 (IL-18) is a key mediator of kidney damage in CKD. Here we will explore how IL-18 causes kidney damage and whether IL-18 may be used as a diagnostic for early detection of CKD, and a target for more effective therapies to treat CKD.
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INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
  • 批准号:
    nhmrc : 1143674
  • 项目类别:
    Project Grants
  • 资助金额:
    $67.84万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Ashley Mansell
  • 依托单位:
Regulation of immune responses in the adult testis and male reproductive health
  • 批准号:
    nhmrc : GNT1125149
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.79万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Ashley Mansell
  • 依托单位:
Regulation of immune responses in the adult testis and male reproductive health
  • 批准号:
    nhmrc : 1125149
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.53万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Ashley Mansell
  • 依托单位:
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
  • 批准号:
    nhmrc : GNT1107804
  • 项目类别:
    Project Grants
  • 资助金额:
    $71.2万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Ashley Mansell
  • 依托单位:
国内基金
海外基金
Interleukin1β炎症通路通过促进精胺代谢介 导抗癫痫药多药耐药的作用及机制研究
  • 批准号:
    Q24H310010
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    汤莹莹
  • 依托单位:
凝血酶介导的 Interleukin-33 活化在二型免疫反应中功能机制研究
白介素-1受体相关激酶(Interleukin-1 receptor associated kinase,IRAK)-M调节哮喘气道炎症异质性和气道重塑以及相关机制的研究
Interleukin-1α和 Interleukin-1β调节大鼠Leydig干细胞增殖和分化的机制研究
  • 批准号:
    LY19H040005
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2018
  • 负责人:
    曹淑彦
  • 依托单位: