Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer
Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer
批准号:
nhmrc : 490956
负责人:
A/Pr Ashley Mansell
金额:
$11.66万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2008-12-31
中文摘要
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英文摘要
Stomach cancer is the second most common cause of cancer-related deaths worldwide, and results in the yearly death of several thousand people in Australia alone. We have discovered a specific mutation in a gene called gp130 that results in the formation of gastritis and stomach cancer in mice. We are now aiming to understand the exact molecular events by which this mutation results in chronic inflammation and the subsequent uncontrolled growth of epithelial cells that line the stomach wall.
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依托单位:
INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
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Regulation of immune responses in the adult testis and male reproductive health
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负责人:A/Pr Ashley Mansell
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依托单位:
Regulation of immune responses in the adult testis and male reproductive health
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批准号:nhmrc : 1125149
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依托单位:
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
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依托单位:
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
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PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
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批准号:nhmrc : 1079924
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财政年份:2015
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依托单位:
PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
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财政年份:2015
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财政年份:2014
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依托单位:
Targeting renal and vascular inflammation in hypertension
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批准号:nhmrc : 1062721
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项目类别:Project Grants
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资助金额:$52.12万
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财政年份:2014
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负责人:A/Pr Ashley Mansell
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依托单位:
Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
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批准号:nhmrc : 1003326
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项目类别:Project Grants
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财政年份:2011
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负责人:A/Pr Ashley Mansell
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依托单位:
Toll-like receptor and MyD88 signalling in the testis
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批准号:nhmrc : 1011115
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项目类别:NHMRC Project Grants
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资助金额:$33.23万
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财政年份:2011
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负责人:A/Pr Ashley Mansell
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依托单位:
H1N1 Development of a signature for early responses to influenza strains that determine -correlate with severity of infe
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批准号:nhmrc : 606976
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项目类别:NHMRC Strategic Awards
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资助金额:$21.29万
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财政年份:2009
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依托单位:
Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)
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批准号:nhmrc : 491017
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项目类别:NHMRC Project Grants
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资助金额:$36.16万
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财政年份:2008
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负责人:A/Pr Ashley Mansell
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依托单位:
Negative regulation and immune subversion of Toll-like receptor signaling pathways
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批准号:nhmrc : 465116
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项目类别:Career Development Fellowships
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资助金额:$31.41万
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财政年份:2007
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负责人:A/Pr Ashley Mansell
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依托单位:
The role of Mal in Toll-like receptor signal transduction of the pro-inflammatory response.
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批准号:nhmrc : 334023
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项目类别:NHMRC Project Grants
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资助金额:$31.51万
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财政年份:2005
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负责人:A/Pr Ashley Mansell
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依托单位:
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